Effectiveness of daily chlorhexidine bathing for reducing gram-negative infections: A meta-analysis

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Aditi PatelAbhishek Deshpande

Abstract

Multiple studies have demonstrated that daily chlorhexidine gluconate (CHG) bathing is associated with a significant reduction in infections caused by gram-positive pathogens. However, there are limited data on the effectiveness of daily CHG bathing on gram-negative infections. The aim of this study was to determine whether daily CHG bathing is effective in reducing the rate of gram-negative infections in adult intensive care unit (ICU) patients. We searched MEDLINE and 3 other databases for original studies comparing daily bathing with and without CHG. Two investigators extracted data independently on baseline characteristics, study design, form and concentration of CHG, incidence, and outcomes related to gram-negative infections. Data were combined using a random-effects model and pooled relative risk ratios (RRs), and 95% confidence intervals (CIs) were derived. In total, 15 studies (n = 34,895 patients) met inclusion criteria. Daily CHG bathing was not significantly associated with a lower risk of gram-negative infections compared with controls (RR, 0.89; 95% CI, 0.73-1.08; P = .24). Subgroup analysis demonstrated that daily CHG bathing was not effective for reducing the risk of gram-negative infections caused by Acinetobac...Continue Reading

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Citations

Jan 10, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Shannon A NovosadDavid Kuhar
May 12, 2019·Clinical Transplantation·Lilian M AbboUNKNOWN AST ID Community of Practice
Oct 8, 2020·Critical Care : the Official Journal of the Critical Care Forum·Hye Ju YeoWoo Hyun Cho
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Jan 31, 2021·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Diego FerianiCely S Abboud

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