PMID: 16538115Mar 16, 2006Paper

Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anaemia: a pilot study

European Journal of Gastroenterology & Hepatology
Ioannis KoutroubakisElias A Kouroumalis

Abstract

The combination of intravenous iron and recombinant human erythropoietin has been proved to be effective in the treatment of refractory anaemia in patients with inflammatory bowel disease (IBD). Darbepoetin-alpha (DPO) has a three-fold longer terminal half-life than erythropoietin. The purpose of this pilot study was to determine whether darbepoetin-alpha is also effective for the treatment of refractory anaemia in IBD. Twenty IBD patients (nine ulcerative colitis and 11 Crohn's disease) and refractory anaemia received intravenous iron sucrose (total iron dose 1.3+/-0.5 g, range 0.7-1.9) and darbepoetin-alfa at the single, weekly dose of 0.9 microg/kg subcutaneously for 4 weeks. Serum erythropoietin, ferritin, transferrin, soluble transferrin receptor, C-reactive protein and interleukin-6 were measured at baseline and after treatment. Haematopoietic response (increase of haemoglobin > or = 2.0 g/dl) was observed in 15 out of the 20 patients (75%). The mean haemoglobin concentrations increased from 9.48+/-0.82 g/dl at baseline to 12.71+/-1.12 g/dl after treatment (P<0.0001). Mean corpuscular volume and serum ferritin levels were also significantly increased whereas mean C-reactive protein levels and endogenous erythropoietin lev...Continue Reading

References

Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·J E Lennard-Jones
Mar 7, 1996·The New England Journal of Medicine·S SchreiberA Raedler
Oct 15, 1998·Gut·R S WalmsleyR N Allan
Sep 1, 2000·European Journal of Internal Medicine·D K Christodoulou, E V Tsianos
Apr 20, 2001·British Journal of Cancer·J C Egrie, J K Browne
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Iain C MacdougallUNKNOWN NESP 960245/246 Study Group
Mar 31, 2004·The American Journal of Medicine·Alisa WilsonJosh Ofman
Jun 8, 2004·Scandinavian Journal of Gastroenterology·G BodemarB G Danielson
Jul 13, 2004·Gut·C GascheG Weiss
Oct 7, 2004·Journal of the American Society of Nephrology : JASN·Denis CournoyerUNKNOWN Canadian PRCA Focus Group

❮ Previous
Next ❯

Citations

Nov 7, 2007·Inflammatory Bowel Diseases·Christoph GascheGert Van Assche
Oct 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jürgen SteinAxel U Dignass
Jan 18, 2011·Hematology·Gary J Vanasse, Nancy Berliner
Sep 30, 2009·World Journal of Gastroenterology : WJG·Fernando Gomollón, Javier P Gisbert
Sep 30, 2009·World Journal of Gastroenterology : WJG·Rosario Moreno LópezFernando Gomollón García
Apr 8, 2014·World Journal of Gastroenterology : WJG·Danila Guagnozzi, Alfredo J Lucendo
Sep 24, 2011·Journal of Crohn's & Colitis·Pantelis OustamanolakisElias A Kouroumalis
Oct 9, 2012·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation
Dec 1, 2007·Journal of Crohn's & Colitis·Konstantinos KatsanosGert Van Assche
Apr 12, 2015·Scandinavian Journal of Gastroenterology·Shinji NakamuraYoshiyuki Nakajima
Dec 18, 2014·Journal of Crohn's & Colitis·Axel U DignassUNKNOWN European Crohn’s and Colitis Organisation [ECCO]
Jun 6, 2009·The American Journal of Gastroenterology·Stefanie KulniggChristoph Gasche
Jan 9, 2007·Alimentary Pharmacology & Therapeutics·S Kulnigg, C Gasche
May 15, 2008·The American Journal of Gastroenterology·Javier P Gisbert, Fernando Gomollón
Feb 7, 2018·Current Treatment Options in Gastroenterology·Dhruvan PatelNabeel Khan
Jul 1, 2014·Frontline Gastroenterology·Martyn Dibb, Sreedhar Subramanian
May 8, 2018·British Journal of Haematology·Gaetano BergamaschiGino R Corazza
May 16, 2018·Therapeutic Advances in Gastroenterology·Dorothea NiepelJan Wehkamp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.