Effectiveness of decision aids for female BRCA1 and BRCA2 mutation carriers: a systematic review

BMC Medical Informatics and Decision Making
Lisa KrassuskiSibylle Kautz-Freimuth

Abstract

Female BRCA1 and BRCA2 mutation carriers have an increased lifetime risk of developing breast and/or ovarian cancer. Hence, they face the difficult decision of choosing a preventive strategy such as risk-reducing surgeries or intensified breast screening. To help these women during their decision process, several patient decision aids (DA) were developed and evaluated in the last 15 years. Until now, there is no conclusive evidence on the effectiveness of these DA. This study aims 1) to provide the first systematic literature review about DA addressing preventive strategy decisions for female BRCA1 and BRCA2 mutation carriers, 2) to analyze the quality of the existing evidence, 3) to evaluate the effects of DA on decision and information related outcomes, on the actual choice for preventive measure and on health outcomes. A systematic literature review was conducted using six electronic databases (inclusion criteria: DA addressing preventive strategies, female BRCA1 and BRCA2 mutation carriers, 18 to 75 years, knowledge of test result). The quality of the included randomized controlled trials (RCT) was evaluated with the Cochrane Collaboration's risk of bias tool. The quality of included one-group pretest-posttest design studie...Continue Reading

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Citations

Jun 24, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg, Melissa Cheyney
Mar 9, 2021·Journal of Cancer Research and Clinical Oncology·Lena JosfeldJutta Hübner
Jun 7, 2021·BMC Medical Informatics and Decision Making·Sibylle Kautz-FreimuthStephanie Stock
Jun 26, 2021·Geburtshilfe und Frauenheilkunde·Lisa Marlene KrassuskiStephanie Stock
Jul 14, 2021·BMJ Open·Sarah A McGarrigleYvonne P Hanhauser

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Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

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