Effectiveness of dexmedetomidine versus propofol on extubation times, length of stay and mortality rates in adult cardiac surgery patients: a systematic review and meta-analysis

JBI Database of Systematic Reviews and Implementation Reports
John Nguyen, Noel Nacpil

Abstract

To determine the effects of dexmedetomidine versus propofol on extubation time, intensive care unit (ICU) length of stay, total hospital length of stay and in-hospital mortality rates in cardiac surgery patients. Recovery from cardiovascular surgery involves weaning from mechanical ventilation. Mechanical ventilation decreases the work of breathing for patients by inhaling oxygen and exhaling carbon dioxide via a ventilator or breathing machine. Prolonged mechanical ventilation is associated with complications, such as pneumonia and lung injury, and increases the risk of morbidity and mortality. Major risk factors that contribute to lung injury are due to high tidal volumes and barotrauma. Cardiac surgery patients remain on the ventilator postoperatively due to the high dose opioid-based anesthesia and the initial vulnerable hemodynamic state. An important component of postoperative management following cardiac surgery is the use of sedation to reduce the stress response, facilitate assisted ventilation, and provide anxiolysis. Propofol and dexmedetomidine are two common sedative agents with differing pharmacological profiles used to provide comfort and minimize hemodynamic disturbances during this recovery phase. Choice of dru...Continue Reading

References

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Dec 13, 2016·JBI Database of Systematic Reviews and Implementation Reports·John Nguyen, Noel Nacpil

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Citations

Apr 9, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Stephanie FullerYuli Y Kim
Feb 1, 2019·Acta Anaesthesiologica Scandinavica·Mathias MaagaardJørn Wetterslev
Jan 24, 2019·Acta Anaesthesiologica Scandinavica·Mathias MaagaardJørn Wetterslev
Dec 6, 2020·Heart & Lung : the Journal of Critical Care·Aynur KoyuncuNuri Orhan
Nov 11, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Hesham A AbowaliEnrico M Camporesi
May 4, 2021·Current Anesthesiology Reports·Valerie Page, Cathy McKenzie

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