Effectiveness of different accelerated partial breast irradiation techniques for the treatment of breast cancer patients: Systematic review using indirect comparisons of randomized clinical trials

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Gustavo N MartaRachel Riera

Abstract

This systematic review was conducted to compare the effectiveness of different accelerated partial breast irradiation (APBI) techniques for the treatment of breast cancer patients. Numerous (APBI) techniques are available for clinical practice. Systematic review of randomized controlled trials of APBI versus whole breast irradiation (WBI). The data from APBI studies were extracted for the analyses. Indirect comparisons were used to compare different APBI techniques. Ten studies fulfilled the inclusion criteria. A total of 4343 patients were included, most of them with tumor stage T1-T2 and N0. Regarding APBI techniques, six trials used external beam radiation therapy; one intraoperative electrons; one intraoperative low-energy photons; one brachytherapy; and one external beam radiation therapy or brachytherapy. The indirect comparisons related to 5-years local control and 5-years overall survival were not significantly different between APBI techniques. Based on indirect comparisons, no differences in clinical outcomes were observed among diverse APBI techniques in published clinical trials that formally compared WBI to APBI. However wide confidence intervals and high risk of inconsistency precluded a sound conclusion. Further ...Continue Reading

References

Sep 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J BoyagesB Silver
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·G G RibeiroS S Banerjee
Sep 6, 2001·Journal of the National Cancer Institute·A B NattingerM A Gilligan
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Oct 26, 2005·Breast Cancer Research and Treatment·Lydia VotiJan Willem W Coebergh
Dec 24, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·D J DodwellD Ash
May 29, 2007·International Journal of Radiation Oncology, Biology, Physics·Csaba PolgárMiklós Kásler
Sep 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Birgitte V OffersenJens Overgaard
Mar 7, 2013·Annals of Surgical Oncology·Mitchel BarryMonica Morrow
Jun 8, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Csaba PolgárMiklós Kásler
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ivo A OlivottoJim A Julian
Oct 29, 2013·International Journal of Radiation Oncology, Biology, Physics·Núria RodríguezManuel Algara
Dec 7, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gustavo Nader MartaRachel Riera
Jan 22, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lorenzo LiviSimonetta Bianchi
Dec 1, 2013·Research Synthesis Methods·Sarah DoneganCatrin Tudur Smith
Aug 2, 2016·International Journal of Radiation Oncology, Biology, Physics·Jayant S VaidyaMichael Baum
Aug 16, 2016·The Breast : Official Journal of the European Society of Mastology·Philip M P PoortmansLorenzo Livi
Apr 25, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vratislav StrnadJean-Michel Hannoun-Levi
Oct 16, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ritu Raj UpretiDeepak D Deshpande

❮ Previous
Next ❯

Citations

Sep 25, 2019·Nature Reviews. Disease Primers·Nadia HarbeckFatima Cardoso
Dec 13, 2019·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Yazid BelkacemiAlphonse G Taghian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.