Effectiveness of gabapentin pharmacotherapy in chemotherapy-induced peripheral neuropathy

Ginekologia polska
Magdalena MagnowskaEwa Nowak-Markwitz

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common chemotherapy side effect, but its prevention and treatment remains a challenge. Neurotoxicity may lead to dose limitation or even treatment discontinuation, and therefore potentially affect the efficacy of anticancer treatment and long term outcomes. The practice to administer gabapentin for neuropathy may be applicable, but is limited by insufficient studies. The aim of our study was to assess the presence of chemotherapy-induced peripheral neuropathy in ovarian cancer patients treated with first-line paclitaxel and carboplatin chemotherapy and evaluate the effectiveness of gabapentin in treatment of this condition. 61 ovarian cancer patients treated with first line chemotherapy were included in the study. The first phase of the study was to assess neurological condition of each patient by: neuropathy symptoms scale, McGill's scale, neurological deficit and quality of life, during the chemotherapy. In the second phase of the study we evaluated the response to gabapentin treatment in a group of patients who developed neuropathy. 78.7% of the patients developed chemotherapy related neuropathy. During the course of chemotherapy these patients experienced significant ex...Continue Reading

Citations

Feb 15, 2019·Paediatric Drugs·Doralina L Anghelescu, Jessica Michala Tesney
Jul 20, 2019·Clinical Journal of Oncology Nursing·Estelle Autissier
Jul 16, 2019·Current Opinion in Neurology·Paola AlbertiDavid R Cornblath
Aug 30, 2019·BMC Pharmacology & Toxicology·Muhammad ShahidRobert D E Sewell
Nov 30, 2019·Critical Reviews in Oncology/hematology·Eiman Y Ibrahim, Barbara E Ehrlich
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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