Effectiveness of generic direct-acting agents for the treatment of hepatitis C: systematic review and meta-analysis

Bulletin of the World Health Organization
Hugo PerazzoValdilea G Veloso

Abstract

To compare the efficacy of generic direct-acting agents and brand-name medicines for treating hepatitis C virus (HCV) infection by conducting a systematic review and meta-analysis. We searched online databases for studies that reported sustained virological responses 12 weeks after the end of HCV treatment with generic direct-acting agents. We derived pooled proportions of treated patients with a sustained virological response from intention-to-treat and per-protocol analyses. In addition, we calculated the pooled relative risk (RR) of a sustained virological response brand-name versus generic direct-acting agents using a random-effects model (DerSimonian-Laird) from the data available. Between-study heterogeneity was assessed using the I2 statistic. We identified 19 studies involving a total of 57 433 individuals from eight territories or regions. The pooled overall proportions of patients with a sustained virological response were 98% (95% confidence interval, CI: 97-99; 18 studies; I2  = 94.1%) in per-protocol analyses and 96% (95% CI: 93-98; 8 studies; I2  = 68.1%) in intention-to-treat analyses. The likelihood of a sustained virological response with brand-name medicines was similar to that with generic direct-acting agent...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
May 23, 2012·Journal of Hepatology·René AdamUNKNOWN European Liver and Intestine Transplant Association (ELITA)
Jan 1, 2014·Archives of public health = Archives belges de santé publique·Victoria N NyagaMarc Aerts
Sep 14, 2016·Journal of Hepatology·Stanislas PolUNKNOWN ANRS/AFEF HEPATHER study group
Dec 7, 2016·Systematic Reviews·Mourad OuzzaniAhmed Elmagarmid
Mar 21, 2017·Annals of Internal Medicine·Oluwaseun Falade-NwuliaMark S Sulkowski
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·UNKNOWN Polaris Observatory HCV Collaborators
Oct 4, 2017·Journal of Clinical and Experimental Hepatology·Aabha NagralRashid Merchant
Mar 1, 2018·Revista médica de Chile·José Ignacio VargasAlejandro Soza
Apr 21, 2018·Liver International : Official Journal of the International Association for the Study of the Liver· Manoj KumarShiv K Sarin
Aug 6, 2018·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mai AbozeidImam Waked
Nov 9, 2018·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Samantha MyersSilvia Alessi-Severini
Nov 22, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Fabiane Mateus SiqueiraRoberto Pontarolo
Nov 26, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Andrea LombardiUNKNOWN ESCMID Study Group for Viral Hepatitis (ESGVH)
Feb 15, 2019·The New England Journal of Medicine·Elize M da FonsecaFrancisco I Bastos

❮ Previous
Next ❯

Citations

Sep 23, 2020·Wellcome Open Research·Huyen Anh NguyenHugo C Turner
Jul 30, 2020·Seminars in Liver Disease·Jean-Michel PawlotskyJeffrey V Lazarus
Dec 10, 2020·Journal of Pharmaceutical Health Care and Sciences·Yuhei HamadaItsuko Ishii

❮ Previous
Next ❯

Software Mentioned

REDCap
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.