Effectiveness of haloperidol prophylaxis in critically ill patients with a high risk of delirium: a systematic review

JBI Database of Systematic Reviews and Implementation Reports
Eduardo SantosJoão Apóstolo

Abstract

Delirium is associated with increased intensive care unit and hospital length of stay, prolonged duration of mechanical ventilation, unplanned removal of tubes and catheters, and increased morbidity and mortality. Prophylactic treatment with low-dose haloperidol may have beneficial effects for critically ill patients with a high risk of delirium. To identify the effectiveness of haloperidol prophylaxis in critically ill patients with a high risk for delirium. Patients with a predicted high risk of delirium, aged 18 years or over, and in intensive care units. Patients with a history of concurrent antipsychotic medication use were excluded. Haloperidol prophylaxis for preventing delirium. Experimental and epidemiological study designs. Primary outcome is the incidence of delirium. Secondary outcomes are duration of mechanical ventilation, incidence of re-intubation, incidence of unplanned/accidental removal of tubes/lines and catheters, intensive care unit and hospital length of stay, and re-admissions to both settings. An initial search of MEDLINE and CINAHL was undertaken, followed by a second search for published and unpublished studies from January 1967 to September 2015 in major healthcare-related electronic databases. Studi...Continue Reading

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Citations

Mar 13, 2018·Current Opinion in Psychiatry·Mary V Seeman, Alexandre González-Rodríguez
Mar 9, 2018·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ying-Zi ShenFu-Hai Ji
Sep 3, 2019·Annals of Internal Medicine·Esther S OhKarin J Neufeld
Feb 6, 2020·BMJ Evidence-based Medicine·Carl Heneghan, Jack O'Sullivan

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