Effectiveness of hexavalent vaccines against invasive Haemophilus influenzae type b disease: Germany's experience after 5 years of licensure

Vaccine
Helen KaliesRüdiger von Kries

Abstract

Vaccine effectiveness (VE) was determined with a case-cohort approach using Cox regression. Cases with confirmed systemic Hib infections in children born from 1 August 2000 to 31 December 2004 were ascertained through two independent nationwide active surveillance systems. A representative cohort of 1303 children born in the same time frame was randomly sampled in a nationwide immunisation survey. Thirty cases were eligible for VE calculation; 19 were unvaccinated and 11 vaccinated with hexavalent vaccines. VE was 68.4% (95% CI: 19.0-87.6) for incomplete primary series and 90.4% (95% CI: 70.6-96.8) for the full primary series. For full immunisation VE was 100.0% (95% CI: 52.7-100.0). Hexavalent vaccines show a high effectiveness against invasive Hib disease in Germany.

References

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Citations

Aug 28, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sohita Dhillon
Aug 10, 2012·Paediatric Drugs·Katherine A Lyseng-Williamson, Sohita Dhillon
Jun 3, 2009·Expert Review of Vaccines·Fred ZeppJeanne-Marie Jacquet
Nov 3, 2011·Expert Review of Vaccines·Ray BorrowJan Poolman
Jun 23, 2009·Expert Review of Vaccines·Craig WhiteDavid W Scheifele
Feb 24, 2016·Journal of Immunology Research·Adi Essam ZareiElrashdy M Redwan
Apr 23, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Sofia ÁguedaAna Maia
Jul 29, 2015·Pediatrics·Gary S MarshallAndrew W Lee

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