Effectiveness of infection-containment measures on SARS-CoV-2 seroprevalence and circulation from May to July 2020, in Milan, Italy

PloS One
Valeria CentoCarlo Federico Perno

Abstract

Through a hospital-based SARS-CoV-2 molecular and serological screening, we evaluated the effectiveness of two months of lockdown and two of surveillance, in Milan, Lombardy, the first to be overwhelmed by COVID-19 pandemics during March-April 2020. All subjects presenting at the major hospital of Milan from May-11 to July-5, 2020, underwent a serological screening by chemiluminescent assays. Those admitted were further tested by RT-PCR. The cumulative anti-N IgG seroprevalence in the 2753 subjects analyzed was of 5.1% (95%CI = 4.3%-6.0%), with a peak of 8.4% (6.1%-11.4%) 60-63 days since the peak of diagnoses (March-20). 31/106 (29.2%) anti-N reactive subjects had anti-S1/S2 titers >80 AU/mL. Being tested from May-18 to June-5, or residing in the provinces with higher SARS-CoV-2 circulation, were positively and independently associated with anti-N IgG reactivity (OR [95%CI]: 2.179[1.455-3.264] and 3.127[1.18-8.29], respectively). In the 18 RT-PCR positive, symptomatic subjects, anti-N seroprevalence was 33.3% (95% CI: 14.8%-56.3%). SARS-CoV-2 seroprevalence in Milan is low, and in a downward trend after only 60-63 days since the peak of diagnoses. Italian confinement measures were effective, but the risk of contagion remains c...Continue Reading

References

Mar 29, 2014·Virus Research·Benjamin MeyerMarcel A Müller
Apr 15, 2020·The New England Journal of Medicine·Daniel F GudbjartssonKari Stefansson
Jun 20, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang

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Citations

Feb 4, 2021·Italian Journal of Pediatrics·Alberto VillaniCarlo Concato
Apr 7, 2021·The Journal of Pediatrics·Christèle Gras-Le GuenRobert Cohen
May 1, 2021·International Journal of Environmental Research and Public Health·Silvano GallusLuigi Paglia
May 6, 2021·International Journal of Environmental Research and Public Health·Francesco NapolitanoItalo Francesco Angelillo

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Methods Mentioned

BETA
Assay
PCR

Software Mentioned

SPSS

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