Effectiveness of interventions for the treatment of acute and prevention of recurrent gout--a systematic review

Rheumatology
S SutariaM Underwood

Abstract

To determine the evidence for the effectiveness of treatments for acute gout and the prevention of recurrent gout. Seven electronic databases were searched for randomized controlled trials of treatments for gout from their inception to the end of 2004. No language restrictions were applied. All randomized controlled trials of treatments routinely available for the treatment of gout were included. Trials of the prevention of recurrence were included only if patients who had had gout and had at least 6 months of follow-up were studied. We found 13 randomized controlled trials of treatment for acute gout, two of which were placebo controlled. Colchicine was found to be effective in one study; however, the entire colchicine group developed toxicity. The only robust conclusion from studies of non-steroidal anti-inflammatory drugs is that pain relief from indometacin and etoricoxib are equivalent. We found one randomized controlled trial, reported only as a conference abstract, of recurrent gout prevention. The shortage of robust data to inform the management of a common problem such as gout is surprising. All of the drugs used to treat gout can have serious side effects. The incidence of gout is highest in the elderly population. It...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Rheumatology. Supplement·A Ruotsi, U Vainio
Apr 1, 1979·Arthritis and Rheumatism·G I WeinerH M Rubinstein
Aug 25, 1979·The Medical Journal of Australia
Feb 1, 1977·Annals of the Rheumatic Diseases·R A SturgeC Engler
Apr 1, 1977·Arthritis and Rheumatism·S L WallaceT F Yü
Jan 1, 1991·Current Medical Research and Opinion·A MaccagnoA Romanowicz
Jan 1, 1990·Rheumatology International·M Pena
Jun 1, 1987·Australian and New Zealand Journal of Medicine·M J AhernM Jones
Nov 27, 1986·The New England Journal of Medicine·B EttingerT Williams
Mar 1, 1987·The American Journal of Medicine·E W CampionL O DeLabry
Nov 1, 1985·British Journal of Clinical Pharmacology·R C ButlerJ T Scott
Jan 1, 1986·Arthritis and Rheumatism·J Z Singer, S L Wallace
Jul 1, 1973·Annals of the Rheumatic Diseases·C J Smyth, J S Percy
May 1, 1970·Annals of Physical Medicine·G Douglas, M Thompson
Oct 1, 1965·Arthritis and Rheumatism·J B Houpt
Oct 1, 1965·Arthritis and Rheumatism·C J Smyth
Nov 1, 1966·Annals of the Rheumatic Diseases·J T Scott
Aug 6, 1966·British Medical Journal·J T ScottR Grahame
Feb 1, 1984·British Journal of Rheumatology·T GibsonA V Rodgers
Jan 1, 1980·Current Medical Research and Opinion·J A ReardonJ T Scott
Feb 1, 1982·Annals of the Rheumatic Diseases·T GibsonH A Simmonds
Mar 1, 1993·The Annals of Pharmacotherapy·F Arellano, J A Sacristán
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Sep 30, 1999·Current Opinion in Rheumatology·N SchlesingerH R Schumacher
Jun 22, 2002·BMJ : British Medical Journal·H Ralph SchumacherJavier Molina
Jul 16, 2003·Clinical Therapeutics·Karissa Y KimSheldon X Kong
Dec 4, 2003·BMJ : British Medical Journal·Ian MorrisPeter Mattingly
Mar 12, 2004·The New England Journal of Medicine·Hyon K ChoiGary Curhan
Jul 15, 2004·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·Jian-ying MaZheng Zhou
Aug 31, 2004·Arthritis and Rheumatism·Jeffry D Bieber, Robert A Terkeltaub

❮ Previous
Next ❯

Citations

Feb 4, 2011·The New England Journal of Medicine·Tuhina Neogi
Feb 7, 2007·Current Opinion in Rheumatology·Eliseo Pascual, Francisca Sivera
Nov 14, 2007·International Journal of Clinical Practice·G I VarugheseM Reddy
Jul 3, 2009·International Journal of Clinical Practice·M E FalagasP I Rafailidis
Jun 3, 2006·BMJ : British Medical Journal·Martin Underwood
Sep 29, 2006·Arthritis Research & Therapy·George I Varughese, Abraham I Varghese
Feb 20, 2010·Clinical Interventions in Aging·Mattheus K Reinders, Tim L Th A Jansen
Apr 11, 2014·International Journal of Rheumatology·Valderilio Feijó AzevedoMauricio Carvalho
Jul 27, 2007·Rheumatology International·Francesco De LeonardisFrancesco Trotta
Feb 22, 2012·Current Rheumatology Reports·Kathrin LottmannPeter K Schädlich
Mar 18, 2008·The American Journal of the Medical Sciences·Yewon ChungRichard O Day
Oct 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Howard S SmithJoshua M Smith
Aug 19, 2011·The American Journal of Geriatric Pharmacotherapy·Michelle A Fravel, Michael E Ernst
Mar 9, 2011·La Revue de médecine interne·J-J DubostM Soubrier
Jan 12, 2010·Internal Medicine Journal·S R GnanenthiranH P McNeil
Apr 16, 2015·International Journal of Rheumatic Diseases·Nicholas J KennedyAndrew A Harrison
Jul 4, 2012·The Journal of Hand Surgery·Peter C Chimenti, Warren C Hammert
May 14, 2011·Postgraduate Medicine·Paul P Doghramji
Mar 1, 2015·The Foot·Natalie TannerStuart A Metcalfe
Nov 14, 2014·The Cochrane Database of Systematic Reviews·Alison S R KyddClaire Bombardier
Mar 17, 2009·The Journal of Rheumatology·John G HanlySander Veldhuyzen van Zanten
Jun 3, 2008·Arthritis and Rheumatism·Oana Popa-NitaPaul H Naccache
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oana Popa-NitaPaul H Naccache
Apr 22, 2008·The Cochrane Database of Systematic Reviews·H J E M JanssensE H Van de Lisdonk
Aug 1, 2020·Expert Opinion on Drug Safety·Giovanna RosasKenneth G Saag
Oct 2, 2009·Deutsches Ärzteblatt International·Anne-Kathrin TauscheUlf Müller-Ladner
Oct 23, 2020·Dose-response : a Publication of International Hormesis Society·Saeed AhmadGhulam Rasool

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.