Effectiveness of Intraoperative Parathyroid Monitoring (ioPTH) in predicting a multiglandular or malignant parathyroid disease

International Journal of Surgery
C DobrinjaNicolò de Manzini

Abstract

The main goal of our study was to confirm the usefulness of intra-operative parathyroid hormone (PTH) monitoring (ioPTH) when using minimally invasive techniques for treatment of sporadic Primary hyperparathyroidism (pHTP). Furthermore, we aimed to evaluate if ioPTH monitoring may help to predict the etiology of primary hyperparathyroidism, especially in malignant or multiglandular parathyroid disease. A retrospective review of 125 consecutive patients with pHPT who underwent parathyroidectomy between 2001 and 2016 at the Department of General Surgery was performed. For each patient, the specific preoperative work-up consisted of: high-resolution US of the neck by a skilled sonographer, sestamibi parathyroid scan, laryngoscopy, and serum measurement of PTH, serum calcium levels, and serum 25(OH)D levels. The study included 125 consecutive patients who underwent surgery for pHPT. At the histological examination, we registered 113 patients with simple adenomatous pathology (90,4%), 5 atypical adenomas (4%), 3 cases of parathyroid carcinoma (2,4%),, , and 4 histological exams of different nature (3,2%). Overall, 6 cases (4,8%) of multiglandular disease were found. We reported 10 cases (8%) of recurrent/persistent hyperparathyroidi...Continue Reading

Citations

Oct 31, 2019·Cancers·Nikita N Machado, Scott M Wilhelm
May 22, 2020·Annals of the Royal College of Surgeons of England·R T D'cruzR Parameswaran
Aug 10, 2018·Indian Journal of Endocrinology and Metabolism·Aabid Hassan NaikZafar Amin Shah
Feb 14, 2020·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K LorenzM Elwerr
Dec 22, 2020·Case Reports in Endocrinology·Federico CappellacciPietro Giorgio Calò
Mar 2, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Matthew Philip DaviesSaba P Balasubramanian

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