Abstract
To evaluate the efficacy of propafenone in converting recent-onset atrial fibrillation (AF) lasting < 7 days, 182 patients were treated intravenously with propafenone (Group 1, n = 98) and with placebo 0.9% saline solution (Group 2, n = 84) in a double blind study. The treatment was continued until sinus rhythm (SR) was restored, but for no more than 24 h. Eighty-nine patients treated with propafenone (90.8%) and 27 patients treated with placebo (32.1%) responded to the treatment and SR was restored (p < 0.0005). The mean time for SR restoration was 2.51 +/- 2.77 h in Group 1, and 17.15 +/- 7.8 h in Group 2 (p < 0.0005). In both groups the patients in whom SR was not restored (nonresponders) had larger left atrial size and longer duration of AF than responders at the onset of the arrhythmia. Nonresponders in Group 1 showed a decrease in mean ventricular rate (MVR) from 143 +/- 16 to 101 +/- 18 (p < 0.0005), while in the nonresponders in Group 2 no reduction of MVR was observed. Two patients whose SR was restored with propafenone had sinus standstill lasting 3.4 and 3.8 s, respectively. Propafenone used intravenously is an effective, quick, and safe drug for treating AF. Moreover, it significantly reduces MVR in nonresponders.
References
Sep 15, 1990·The American Journal of Cardiology·C J MurdockC R Kerr
Aug 1, 1989·The American Journal of Cardiology·L BianconiM Pistolese
Mar 1, 1987·The American Journal of Cardiology·I G CrozierL Levy
Aug 25, 1988·The American Journal of Cardiology·J L AndersonP A Fredell
Apr 1, 1987·Annals of Internal Medicine·R H FalkN J Battinelli
Mar 1, 1987·European Heart Journal·M Schlepper
Jun 1, 1987·Journal of the American College of Cardiology·S C HammillD R Holmes
Nov 1, 1986·Annals of Internal Medicine·E N ShenR J Sung
Feb 1, 1985·Australian and New Zealand Journal of Medicine·T P GavaghanJ J Morgan
Jan 1, 1985·International Journal of Cardiology·B StrasbergJ Agmon
Mar 11, 1972·British Medical Journal·L SchamrothC Garrett
May 1, 1983·Archives of Internal Medicine·C TommasoJ V Talano
Mar 1, 1983·European Heart Journal·R Faniel, P Schoenfeld
Dec 1, 1980·American Heart Journal·R A DeSilvaB Lown
Nov 1, 1980·British Heart Journal·S W HalpernW J Mandel
Jul 1, 1954·American Heart Journal·L R PASCALEE F FOLEY
Nov 1, 1964·The American Journal of Medicine·J W HURSTR C SCHLANT
Citations
Mar 16, 2012·Cardiovascular Drugs and Therapy·Lori D BashMkaya Mwamburi
Nov 11, 1998·The American Journal of Cardiology·A P Rae
Sep 25, 1999·The American Journal of Cardiology·P GeelenJ Turgeon
Oct 5, 2001·Journal of the American College of Cardiology·V FusterUNKNOWN American College of Cardiology/American Heart Association/European Society of Cardiology Board
Jan 22, 2003·Journal of the American College of Cardiology·Philippe ChevalierPaul Touboul
Nov 6, 2002·The American Journal of Geriatric Cardiology·Mark Dayer, Suzanna M C Hardman
May 19, 1998·Pacing and Clinical Electrophysiology : PACE·C CosteasJ A Reiffel
Nov 18, 1997·Journal of Cardiovascular Electrophysiology·L I Ganz, E M Antman
May 16, 2002·Heart·G NicholG Wells
Jan 22, 2005·Annual Review of Medicine·Ashish AgarwalMichael Ezekowitz
Feb 6, 2002·Drugs·Giuseppe BorianiAngelo Branzi
Jan 13, 2001·Seminars in Thoracic and Cardiovascular Surgery·R W RhoD Kocovic
Dec 24, 1997·Cardiology Clinics·F A Masoudi, N Goldschlager
Jul 13, 2004·Resuscitation·G NicholL Becker
Mar 12, 2011·Journal of the American College of Cardiology·Valentin FusterL Samuel Wann
Aug 15, 2006·Journal of the American College of Cardiology·Valentin FusterUNKNOWN Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation
Oct 17, 1996·The American Journal of Cardiology·B Olshansky
Aug 4, 2006·European Heart Journal·Valentin FusterUNKNOWN Heart Rhythm Society
Mar 9, 2011·Circulation·Valentin FusterUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force
Aug 16, 2006·Circulation·Valentin FusterUNKNOWN Heart Rhythm Society
Nov 5, 2003·Expert Opinion on Pharmacotherapy·Paul A GouldDavid M Kaye
Nov 10, 2016·Medicine·Mariya NegrevaKaterina Vitlianova
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·A S FakA Oktay
Mar 16, 2001·Expert Opinion on Pharmacotherapy·J Nemec, W K Shen
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·M Valderrábano, B N Singh
Dec 22, 2000·Current Opinion in Cardiology·A Pinter, P Dorian
Jan 6, 2021·Cardiovascular Drugs and Therapy·Dimitris TsiachrisChristodoulos Stefanadis