Effectiveness of Lung-RADS in Reducing False-Positive Results in a Diverse, Underserved, Urban Lung Cancer Screening Cohort

Journal of the American College of Radiology : JACR
Mark KaminetzkyLinda B Haramati

Abstract

The Lung CT Screening Reporting and Data SystemTM (Lung-RADSTM) was created to standardize lung cancer screening CT reporting and recommendations but has not been well validated prospectively in clinical practice. The aim of this study was to determine the effectiveness of lung cancer screening using Lung-RADS in a diverse, underserved, academic clinical screening program, focusing on whether Lung-RADS would successfully reduce the 23.3% false-positive rate found in the National Lung Screening Trial. Institutional review board approval was obtained to study the clinical lung cancer screening cohort. Low-dose CT results were prospectively assigned a Lung-RADS or equivalent score. The proportion of examinations in each Lung-RADS category and the corresponding lung cancer rate, subsequent imaging, interventions, mortality, and compliance were tracked. The National Death Index was queried for follow-up losses. The cohort comprised 1,181 patients with 2,270 person-years of follow-up from December 2012 to December 2016. The mean age was 64 ± 16.2 years, with 51% women, 63% nonwhite, 71% current smokers, 69% overweight and obese, and multiple comorbidities. The Lung-RADS false-positive rate was 10.4% (95% confidence interval, 8.8%-12....Continue Reading

Citations

Sep 19, 2020·Journal of the American College of Radiology : JACR·Anupam BasuSean B Smith
Nov 4, 2020·Southern Medical Journal·Christina BellingerStephen Kuperberg
Nov 17, 2020·JAMA Network Open·Maria A Lopez-OlivoRobert J Volk
Dec 24, 2020·AJR. American Journal of Roentgenology·Jose A B Araujo-FilhoMichelle S Ginsberg
Jun 7, 2021·Seminars in Thoracic and Cardiovascular Surgery·Cherie P ErkmenGrace X Ma
Aug 27, 2021·The Journal of Surgical Research·Brittney M WilliamsGita N Mody
Jul 17, 2021·Chest·Peter J MazzoneFrank C Detterbeck
Oct 9, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yannan LinAshley Elizabeth Prosper
Sep 14, 2021·The Annals of Thoracic Surgery·Lynde K LutzowCherie P Erkmen

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