Effectiveness of multiple pre-ischemia electro-acupuncture on attenuating lipid peroxidation induced by cerebral ischemia in adult rats

Life Sciences
Flora K W SiuMason C P Leung

Abstract

Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA therapy has not been reported. In this study, we aim to investigate the effectiveness of pre-ischemic EA therapy on lipid peroxidation in the rat ischemic injury model. Four groups of Sprague-Dawley rats were designed: Placebo group (without EA therapy), NA group (EA therapy on non-acupoint), GB20 group (EA therapy on Fengchi), and ST36 group (EA therapy on Zusanli). Half of each group (n = 6) received 30-minute EA therapy for 3 times and the other half group for 18 times before the occlusion of right middle cerebral artery. Right brains were taken for determination of concentration of MDA and the total of MDA plus 4-HNE. We found that multiple pre-ischemia EA therapy at either GB20 or ST36 can effectively reduce the amount of MDA produced after MCA occlusion. However, this reduction was not observed in the total amount of MDA and 4-HNE. In conclusion, pre-ischemia EA can partly regulate the lipid peroxidation in cereb...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·H EsterbauerH Zollner
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·C BromontJ Bralet
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·S T ChenJ D Balentine
Nov 1, 1994·Free Radical Biology & Medicine·J J Chen, B P Yu
Oct 28, 1998·Environmental Health Perspectives·F J RomeroJ Romá
May 8, 2001·Archives of Biochemistry and Biophysics·G CighettiP Allevi
Sep 25, 2002·Acupuncture & Electro-therapeutics Research·Paul Tsui, Mason C P Leung

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Citations

Sep 21, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jianfeng GaoChanglian Zhu
Jun 18, 2005·Neuroscience·D YamashitaJ M Miller
Jan 30, 2013·BMC Complementary and Alternative Medicine·Ji Hyun KimHwa Kyoung Shin
Jul 18, 2009·Journal of Experimental & Clinical Cancer Research : CR·Hyo-Jeong LeeSung-Hoon Kim
Feb 6, 2010·Neurological Research·Gi-Ja LeeHun-Kuk Park
May 23, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Xin LiLize Xiong
Jun 9, 2012·Aesthetic Plastic Surgery·Lorena Picanço LimaSergio Botelho Guimarães
Dec 8, 2014·Physiology & Behavior·Qian-Qian LiCun-Zhi Liu
Feb 24, 2006·Clinical Biochemistry·Remziye SivaciOsman Nuri Dilek
Aug 7, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiang-Hong ZengCun-Zhi Liu
Oct 14, 2011·Acta Cirúrgica Brasileira·Agamenon Honório SilvaSérgio Botelho Guimarães
May 4, 2018·Neural Regeneration Research·Qwang-Yuen ChangChing-Liang Hsieh
Mar 25, 2020·Antioxidants·Chao-Hsien Chen, Ching-Liang Hsieh
May 21, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Wen ZhuCun-Zhi Liu
Apr 30, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·A LaiM C Leung
Nov 13, 2020·Oxidative Medicine and Cellular Longevity·Xin-Tong SuCun-Zhi Liu

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