Effectiveness of nafcillin, methicillin, and cephalothin in experimental Staphylococcus aureus endocarditis.

Antimicrobial Agents and Chemotherapy
J CarrizosaD Kaye

Abstract

Nafcillin, methicillin, and cephalothin (40 mg/kg every 6 h) were all effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. Nafcillin and methicillin reduced the number of S. aureus at a significantly faster rate than did cephalothin. Nafcillin and methicillin also reduced titers of the S. aureus more rapidly than did cephalothin in vitro, both in broth and in rabbit serum.

References

Mar 1, 1973·The Journal of Clinical Investigation·D T Durack, R G Petersdorf
Oct 1, 1973·The Journal of Infectious Diseases·M E LevisonD Kaye
Mar 1, 1965·Applied Microbiology·W E WICK, W S BONIECE

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Citations

May 1, 1981·Antimicrobial Agents and Chemotherapy·F M Gengo, J J Schentag
Mar 1, 1982·Antimicrobial Agents and Chemotherapy·F M Gengo, J J Schentag
Jul 1, 1984·Journal of Pharmaceutical Sciences·F M GengoW J Jusko
Sep 10, 2020·Expert Review of Anti-infective Therapy·David Luque PazPierre Tattevin

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