PMID: 9179944Aug 1, 1995Paper

Effectiveness of nilvadipine in two cases of chronic schizophrenia

Psychiatry and Clinical Neurosciences
K YamadaM Asai

Abstract

Nilvadipine is a calcium channel inhibitor used commonly for the treatment of cerebrovascular insufficiency. We observed two patients with schizophrenia whose psychiatric symptoms and tardive dyskinesia improved after the addition of nilvadipine to their antipsychotic drug regimen. The total score of the brief psychiatric rating scale (BPRS) in case 1 fell from 56 to 42 after 8 weeks on nilvadipine; while that of case 2 fell from 44 to 32. The total score of the abnormal involuntary movement scale (AIMS) in case 2 decreased from 12 to 7. No adverse effects occurred during treatment. Nilvadipine may thus offer a new approach to the adjunctive treatment of schizophrenia.

References

Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·G BartkoE Frecska
Feb 1, 1987·Archives of General Psychiatry·D PickarP K Narang
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J GouldS H Snyder

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Citations

Dec 1, 1995·Psychiatry and Clinical Neurosciences·T Inada, G Yagi
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven GeeVikaas S Sohal
Dec 1, 1996·Journal of Clinical Psychopharmacology·K YamadaM Asai
Sep 5, 2019·Scientific Reports·Kalyani B KarunakaranMadhavi K Ganapathiraju

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