Effectiveness of novel folate receptor-mediated staining solution detection (FRD) for cervical cancer screening

Medicine
Yuping DaiDonghong Li

Abstract

Folate receptor-mediated staining solution detection (FRD) has been recently suggested as an effective tool in the cervical cancer screening. We aim to compare the accuracy of FRD to human papillomavirus (HPV) and thinprep cytology test (TCT) based on cytology-based biopsy.During May 2016 and December 2016, we recruited women who presented for routine cervical lesion screening. The eligible cases were nonpregnant women and not in the menstrual period, aging between 25 and 65. All eligible women were screened with TCT, HPV, FRD testing, and colposcopy.A total of 216 women include 137 (63.4%) cases of cervical inflammation, 27 (12.5%) cases of cervical intraepithelial neoplasia 1 (CIN 1), 51 (23.6%) cases of CIN 2, 34 (15.7%) cases of CIN 3, and 12 (5.6%) cases of cervical cancer. The sensitivity were 93.81%, 76.29%, 80.41% for HPV testing, TCT testing, and FRD testing, respectively. The specificities were 16.46%, 34.15%, and 68.29%, respectively. FRD has statistically significant higher specificity than HPV testing and TCT (both P < .05). However, no differences were found in sensitivity (both P > .05). The positive predictive value (PPV), negative predictive value (NPV), and Kappa consistency coefficient were 39.91%, 81.82%, an...Continue Reading

References

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Citations

May 30, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yun ZhaoLihui Wei

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS

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