PMID: 9631313Jun 19, 1998Paper

Effectiveness of omeprazole-amoxicillin-clarithromycin (OAC) therapy for Helicobacter pylori infection in a Japanese population

Helicobacter
H MiwaN Sato

Abstract

Omeprazole or lansoprazole, amoxicillin, clarithromycin (PPI/AC) therapy has been reported to provide a high cure rate of H. pylori infection with few adverse effects. Effectiveness of H. pylori therapy may vary among different geographic regions and patient populations. However, there are few reports in Japan as to its effectiveness. We have, therefore, studied the effectiveness of H. pylori therapy in a large group of Japanese patients. For this study, 366 H. pylori-positive patients with peptic ulcer disease or non-ulcer dyspepsia (263 men and 103 women, mean age 48.5 years) were assigned to 6 groups, each receiving a different PPI/AC regimen. Group 1 received omeprazole (OPZ) 20 mg, amoxicillin (AMOX) 1500 mg, and clarithromycin (CAM) 400 mg; Group 2 OPZ 40 mg, AMOX 1500 mg, and CAM 400; and Group 3 OPZ 20 mg, AMOX 2000 mg, and CAM 600 mg daily for 14 days. The group treated with lansoprazole (LPZ) 30 mg, AMOX 1500 mg and CAM 400 mg was used for 14 days in Group 1L. OPZ 20 mg, AMOX 750 mg, and CAM 200 mg were given to Group 4 for 28 days and OPZ 20 mg, AMOX 1500 mg, CAM 400 mg was administered to Group 5 for 7 days. Cure of infection was assessed by 13C urea breath test one month after completion of therapy. Cure rates calc...Continue Reading

References

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Citations

Apr 12, 2000·Journal of Gastroenterology and Hepatology·H Miwa, N Sato
Jun 26, 2001·Journal of Gastroenterology and Hepatology·A NagaharaN Sato
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Chieko KatoKazuyuki Suzuki
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Dec 18, 2013·The Cochrane Database of Systematic Reviews·Yuhong YuanPaul Moayyedi
Mar 17, 2007·Renal Failure·Tomoko ItatsuYasuo Hayashida
Jun 26, 2001·Alimentary Pharmacology & Therapeutics·X CalvetI Sanfeliu
Jul 30, 2002·Alimentary Pharmacology & Therapeutics·X CalvetUNKNOWN Group for Eradication Studies from Catalonia and Aragón (Gresca)

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