Abstract
To systematically review the effectiveness of oral baclofen versus placebo or other antispastic oral medications in terms of body function, level of activity, and quality of life in children and adolescents with spastic cerebral palsy who are younger than 18 years. Cochrane Library, Health Science Databases, DARE, LILACS, Embase, MEDLINE, OTseeker, PEDro, PsycINFO, SpeechBITE, ScienceDirect, Scopus, Trip, ClinicalTrials.gov, Google Scholar, OpenGrey, and manual search. Randomized or not randomized controlled trials and cohort studies comparing the effect of any dosage of oral baclofen with that of no treatment, placebo, or another antispastic medication in children and adolescents with spastic cerebral palsy were selected. Following the Cochrane Handbook for Systematic Reviews of Interventions guidelines, 2 reviewers independently searched articles in databases from their inceptions until October 2014. Six randomized controlled trials involving a total of 130 patients were selected. Studies show a great variability in motor classification, dosage of baclofen, and outcome measures. There is conflicting evidence on the effectiveness of oral baclofen in reducing muscle tone or improving motor function or the level of activity. The...Continue Reading
References
Jan 1, 1992·The Journal of Physiology·S M Thompson, B H Gähwiler
Mar 1, 1992·Neurology·M Kofler, A Arturo Leis
Jun 1, 1990·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·K J Ottenbacher, A Cusick
Jun 1, 1988·American Journal of Physical Medicine & Rehabilitation·R T Katz
Sep 1, 1974·Journal of the Neurological Sciences·N E CartlidgeD Weightman
Sep 1, 1981·Archives of Neurology·C F Terrence, G H Fromm
Nov 24, 1993·JAMA : the Journal of the American Medical Association·A L AlbrightJ Janosky
Feb 1, 1993·Journal of Neurosurgery·J R CoffeyB Gill
Mar 1, 1996·Journal of Child Neurology·A L Albright
Jun 2, 1998·Pediatrics·H E PerryA D Woolf
Jan 1, 1997·Muscle & Nerve. Supplement·J M GraciesD M Simpson
May 26, 1999·Journal of Child Neurology·D I ZafeiriouI Tsikoulas
Sep 25, 1999·Clinical Rehabilitation·A D PandyanH Rodgers
Mar 1, 2000·Journal of Child Neurology·R GilmartinJ Nadell
Apr 25, 2000·Drugs·M Kita, D E Goodkin
Feb 28, 2001·Journal of Child Neurology·E M Goldstein
Feb 28, 2001·Journal of Child Neurology·L E Krach
Nov 7, 2002·Developmental Medicine and Child Neurology·William M CampbellKristie Bjornson
Jun 24, 2003·Journal of Rehabilitation Medicine·Anthony B Ward
Oct 1, 2003·Developmental Medicine and Child Neurology·Adrienne L FosangIan Story
Nov 25, 2003·Pediatric Neurology·Donna E HanselAlexander H Hoon
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Jul 29, 2004·Indian Journal of Pediatrics·Pratibha D Singhi
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A J ThompsonV L Stevenson
Dec 27, 2005·Pediatric Neurology·Alberto VerrottiPaola Iannetti
Jun 13, 2006·Clinics in Perinatology·Nigel PanethSteven Korzeniewski
Jul 25, 2006·Disability and Rehabilitation·A B HaughG R Johnson
Oct 19, 2006·Journal of Paediatrics and Child Health·Adam ScheinbergStephen O'Flaherty
Dec 13, 2006·Journal of Child Neurology·Winnie Ka Ling Yam, Milan So Mei Leung
Dec 13, 2006·Journal of Child Neurology·Lisa LubschSherry Luedtke
Jul 25, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Susan Ronan, Joan T Gold
Apr 12, 2008·BMC Musculoskeletal Disorders·Akmer MutluMintaze Kerem Gunel
Feb 21, 2009·Neurorehabilitation and Neural Repair·D BensmailA Beresniak
Dec 25, 2009·Journal of Pediatric Orthopedics·Andrzej BorowskiFreeman Miller
Jan 27, 2010·Neurology·UNKNOWN Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology SocietJ Vargus-Adams
May 5, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chia-Ying ChungAlice May-Kuen Wong
Jun 4, 2011·Developmental Medicine and Child Neurology·Tamis W PinMary-Clare Waugh
Mar 1, 2012·BMJ : British Medical Journal·Asbjørn HróbjartssonStig Brorson
Dec 18, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Takaomi TairaHirokazu Tanabe
May 8, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Rachel HalpernRichard D Zorowitz
Nov 26, 2013·Archives of Physical Medicine and Rehabilitation·Virginia Way Tong ChuBrian David Schmit
Mar 13, 2014·The Journal of Pediatrics·Yang HeWilliam J Jusko
Citations
Feb 11, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Anton BespalovEdwin Zvartau
Jun 23, 2016·Journal of Neurotrauma·Angela Navarrete-OpazoCarolina Astudillo
May 17, 2018·Topics in Stroke Rehabilitation·Shiho MizunoSonoda Shigeru
Nov 27, 2018·Journal of Motor Behavior·Shaghayegh ModaberiNasser Naghdi
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qingfeng HeDaryl J Murry
Feb 23, 2020·Current Neurology and Neuroscience Reports·Iona NovakNadia Badawi
Apr 6, 2021·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Ishan RadotraStuart W McKirdy
Aug 13, 2021·Neurosurgery·Mark A MahanSteven R Edgley