Effectiveness of oral propafenone for the prevention of atrial fibrillation after coronary artery bypass grafting

The American Journal of Cardiology
Peter R KoweyCOPPA-II Investigators

Abstract

The efficacy and safety of oral propafenone for the prevention of atrial fibrillation (AF) were tested in a group of 293 patients who underwent coronary artery bypass grafting. Patients were randomized to placebo or 1 of 2 doses of propafenone. Patients treated with propafenone 675 mg/day compared with placebo had a nonsignificantly reduced incidence of AF and did not have a reduction in length of stay. Adverse events and discontinuations for untoward events were equal among the 3 groups.

References

Dec 4, 1996·JAMA : the Journal of the American Medical Association·S S Khan
May 24, 2000·The American Journal of Cardiology·D B Bharucha, P R Kowey
Mar 29, 2001·Pacing and Clinical Electrophysiology : PACE·P R KoweyR A Marinchak

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Citations

Aug 18, 2005·Current Cardiology Reports·Orhan OnalanEugene Crystal
May 17, 2005·Journal of the American College of Cardiology·Leonardo CalòMassimo Santini
Feb 14, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gheorghe-Andrei DanUNKNOWN ESC Scientific Document Group
Dec 5, 2006·Current Opinion in Cardiology·L Brent Mitchell
Feb 23, 2019·Nature Reviews. Cardiology·Dobromir DobrevStanley Nattel

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