Effectiveness of oral rotavirus vaccination in England against rotavirus-confirmed and all-cause acute gastroenteritis

Vaccine: X
Jemma L WalkerSara L Thomas

Abstract

The monovalent oral rotavirus vaccine Rotarix® was introduced into the UK infant immunisation programme in 2013. We estimated vaccine effectiveness (VE) in the first two years of the programme. We used a test-negative case-control design and enhanced national surveillance data for 1869 vaccine-eligible children tested for rotavirus infection to obtain adjusted odds ratios and VE against laboratory-confirmed rotavirus infections. Linked anonymised UK primary care and hospitalisation data from the Clinical Practice Research Datalink (40,723 children) and random-effects Poisson regression were used in a cohort study to estimate VE against all-cause acute gastroenteritis (AGE) and AGE hospitalisations. VE against laboratory-confirmed infection was 69% (95% Confidence Interval: 40-84%) for one dose and 77% (95%CI: 66-85%) for two doses. Two-dose VE in children aged <12 months and ≥12 months was 85% (95%CI: 74-91%) and 54% (95%CI: 15-75%), respectively. In contrast, we found no evidence that the vaccine was effective against all-cause AGE (VE = -20%, 95%CI: -36% to -5%), or against AGE hospitalisations (VE = 35%, 95% CI: -86% to 77%). In this first detailed assessment of VE of the Rotarix® vaccine in the English national programme, w...Continue Reading

Citations

Nov 25, 2020·The Pediatric Infectious Disease Journal·Josephine A P van DongenUNKNOWN RIVAR Study Group
May 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charlotte M GowerShamez N Ladhani
Aug 23, 2020·The Lancet Global Health·Eleanor BurnettJacqueline E Tate

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Datasets Mentioned

BETA
JX943612

Methods Mentioned

BETA
nucleic acid amplification
PCR

Software Mentioned

Stata MP
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