Effectiveness of pediatric antiretroviral therapy in resource-limited settings: a systematic review and meta-analysis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Andrea L CiaranelloRochelle P Walensky

Abstract

Responses to antiretroviral therapy (ART) among human immunodeficiency virus (HIV)-infected children in resource-limited settings have recently been reported, but outcomes vary. We sought to derive pooled estimates of the 12-month rate of virologic suppression (HIV RNA, <400 copies/mL) and gain in CD4 cell percentage (DeltaCD4%) for children initiating ART in resource-limited settings. We conducted a systematic review and meta-analysis of published reports of HIV RNA and CD4 outcomes for treatment-naive children aged 0-17 years old by means of the Medline, EMBASE (Excerpta Medica Database), and LILACS (Latin American and Caribbean Health Sciences Literature) electronic databases and the Cochrane Clinical Trials Register. Pooled estimates of the reported proportion with HIV RNA <400 copies/mL and DeltaCD4% after 12 months of ART were derived using patient-level estimates and fixed- and random-effects models. To approximate intention-to-treat analyses, in sensitivity analyses children with missing 12-month data were assumed to have HIV RNA>400 copies/mL or DeltaCD4% of zero. In patient-level estimates after 12 months of ART, the pooled proportion with virologic suppression was 70% (95% confidence interval [CI], 67%-73%); the pool...Continue Reading

References

May 3, 2001·The Pediatric Infectious Disease Journal·J EmbreeF Plummer
Jan 17, 2002·The New England Journal of Medicine·S L GortmakerUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 219 Team
Mar 21, 2002·The Lancet Infectious Diseases·Annemarie M C van RossumRonald de Groot
Mar 14, 2003·The Pediatric Infectious Disease Journal·Xavier Sáez-LlorensEugene Sun
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 1, 2003·BMJ : British Medical Journal·D M GibbUNKNOWN National Study of HIV in Pregnancy and Childhood Collaborative HIV Paediatric Study
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louise C IversKaren Doucette
Apr 29, 2006·The Pediatric Infectious Disease Journal·Katja DoerholtUNKNOWN Collaborative HIV Paediatric Study
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Salvador ResinoUNKNOWN Spanish Group of Pediatric HIV Infection
Jul 20, 2006·JAMA : the Journal of the American Medical Association·Philimon GonaGeorge R Seage
Jan 12, 2007·The New England Journal of Medicine·Shahin LockmanMax Essex
Jan 24, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thanyawee PuthanakitVirat Sirisanthana
Apr 17, 2007·The Journal of Infectious Diseases·Erik GeorgePeter F Wright
Apr 28, 2007·American Journal of Public Health·Patricia MyungJohn Tucker
Aug 19, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Moses R KamyaUNKNOWN Academic Alliance for AIDS Care and Prevention in Africa
Sep 5, 2007·Bulletin of the World Health Organization·Joseph Kwong-Leung YuAnthony D Harries
Oct 24, 2007·JAMA : the Journal of the American Medical Association·Carolyn Bolton-MooreJeffrey S A Stringer
Nov 14, 2007·International Journal of Epidemiology·Elise ArrivéUNKNOWN KIDS-ART-LINC Collaboration
Jul 26, 2008·The Lancet Infectious Diseases·Catherine G SutcliffeWilliam J Moss
Aug 1, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pierre De BeaudrapPhilippe Msellati
Aug 5, 2008·JAMA : the Journal of the American Medical Association·Elvin H GengJeffrey N Martin
Oct 3, 2008·Journal of Tropical Pediatrics·N KumarasamySuniti Solomon
Nov 8, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·UNKNOWN KIDS-ART-LINC Collaboration

❮ Previous
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Citations

Nov 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ricardo OliveiraUNKNOWN NISDI Pediatric Study Group 2010
Nov 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yan ZhaoFujie Zhang
Jul 8, 2011·The Pediatric Infectious Disease Journal·Tammy M MeyersHarry Moultrie
Dec 20, 2012·The Pediatric Infectious Disease Journal·Chloe A TeasdaleLouise Kuhn
Sep 28, 2012·AIDS·Gesine Meyer-RathSydney Rosen
Sep 16, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rawiwan HansudewechakulUNKNOWN TREAT Asia Pediatric HIV Observational Database
Dec 17, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pagakrong LumbiganonUNKNOWN TREAT Asia Pediatric HIV Observational Database (TApHOD)
Dec 1, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dalton C WamalwaJulie Overbaugh
Oct 27, 2011·AIDS Research and Therapy·Torsak BunupuradahJintanat Ananworanich
Jan 26, 2011·Pediatrics·Elizabeth Peacock-VilladaGrace C John-Stewart
Apr 26, 2014·Journal of the International AIDS Society·Fatoumata DickoUNKNOWN Pediatric IeDEA West Africa Working Group
Apr 4, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rapeepan SuaysodGonzague Jourdain
Mar 23, 2010·Journal of the International AIDS Society·Petros IsaakidisRony Zachariah
Oct 5, 2013·AIDS Care·Sumathi SivapalasingamRobert Holzman
Jul 12, 2013·Cadernos de saúde pública·Alberto Novaes RamosJorg Heukelbach
Nov 24, 2016·The Pediatric Infectious Disease Journal·Catherine G SutcliffeWilliam J Moss
Oct 12, 2013·Journal of the International Association of Providers of AIDS Care·Brian P BostAlan S Karstaedt
Apr 27, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michelle S McConnellSombat Thanprasertsuk
Nov 14, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephen ArpadiSabin Nsanzimana
Mar 4, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Martina PenazzatoNathan Ford
Nov 1, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Margaret L McNairyUNKNOWN Identifying Optimal Models of HIV Care and Treatment in Sub-Saharan Africa Consortium
Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Dec 8, 2015·Journal of the International AIDS Society·Ragna S BoermaKim Ce Sigaloff

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