PMID: 6404378Apr 9, 1983Paper

Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia

British Medical Journal
S FranksD R London

Abstract

Twenty five patients with hyperprolactinaemia were treated with pergolide mesylate, a new dopamine receptor agonist. Twenty three received treatment for six to 20 months, and in all serum prolactin concentrations were considerably reduced. In most patients prolactin concentrations were maintained in the normal range by a low, once daily dose of pergolide and reversal of associated reproductive disorders was observed. Tumour volume as assessed by computed tomography decreased considerably during treatment in three out of four patients with a pituitary tumour. The drug was well tolerated. Side effects were similar to those of bromocriptine, but four out of eight patients who had been forced to stop taking bromocriptine because of untoward effects were subsequently able to tolerate treatment with pergolide. Pergolide mesylate promises to be a useful addition to the currently available long acting dopamine agonists in the management of hyperprolactinaemia.

References

Feb 8, 1979·The New England Journal of Medicine·A M McGregorR Hall
Apr 1, 1977·British Journal of Obstetrics and Gynaecology·S FranksJ D Nabarro
Oct 1, 1976·The Journal of Clinical Endocrinology and Metabolism·B MagriniJ P Felber
May 25, 1974·British Medical Journal·M O ThornerG M Besser
Jul 1, 1980·The Journal of Clinical Endocrinology and Metabolism·D L KleinbergM Kupersmith
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R L PerrymanM O Thorner
Aug 14, 1982·British Medical Journal·P Kendall-TaylorR W Prescott

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Citations

May 6, 2005·Treatments in Endocrinology·Johan Verhelst, Roger Abs
Jul 13, 1999·Journal of Endocrinological Investigation·S CannavòF Trimarchi
Nov 1, 1988·Medical Toxicology and Adverse Drug Experience·K Hell, H Wernze
Nov 1, 1983·Clinics in Endocrinology and Metabolism·J P Thomas, R Hall
Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·D T BairdA F Glasier
Nov 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pier Giorgio Crosignani
Apr 1, 1986·Clinical Endocrinology·S R Ahmed, S M Shalet
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·P U FredaS L Wardlaw
Aug 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·B Corenblum

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