Effectiveness of Pharmacological Interventions for Symptoms of Behavioral Variant Frontotemporal Dementia: A Systematic Review

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology
Calvin TrieuAnnemieke Dols

Abstract

Clinical guidance on the symptomatic treatment of behavioral variant frontotemporal dementia (bvFTD) is limited. To provide a systematic review of pharmacological interventions for symptomatic treatment of bvFTD, based on the International bvFTD Criteria Consortium clinical diagnostic criteria: apathy, disinhibition, lack of empathy or sympathy, hyperorality, stereotypical behavior, and executive dysfunction. We systematically searched the PubMed, Embase, and PsycINFO databases for reports on pharmacological interventions for individuals with bvFTD, published between 1970 and 2018, using key indicators and relevant terms. Studies were included if the efficacy of the intervention in alleviating bvFTD symptoms was provided as an outcome. Due to the high prevalence of depressive symptoms in individuals with bvFTD, we also evaluated the effect of the interventions on depression. We included 23 studies-11 randomized controlled trials, eight open-label studies, one proof-of-concept study, and three case series-reporting on a total of 573 individuals. Of the 23 studies, 16 used pharmacological interventions that improved bvFTD symptoms. Based on the Neuropsychiatric Inventory, trazodone had the greatest significant reductive effect on...Continue Reading

References

Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Feb 1, 1988·Biological Psychiatry·G S AlexopoulosC A Shamoian
Dec 14, 1999·European Journal of Pharmacology·M PazzagliG Pepeu
Feb 24, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·K L LanctôtP Mazzotta
Feb 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Julie S SnowdenDavid M A Mann
Jun 12, 2002·Psychiatry Research·Kazue ShigenobuHirotaka Tanabe
Jun 12, 2002·Neurology·E RatnavalliJ R Hodges
Jan 24, 2004·Dementia and Geriatric Cognitive Disorders·Manabu IkedaHirotaka Tanabe
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Manabu IkedaHirotaka Tanabe
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Florence LebertFlorence Pasquier
Nov 24, 2004·Drugs & Aging·Rita MorettiAntonio Bava
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shibley RahmanBarbara J Sahakian
Jun 5, 2007·Alzheimer Disease and Associated Disorders·Margaret M Swanberg
Oct 10, 2007·Acta Neurologica Scandinavica·G MilanA Postiglione
Jan 17, 2008·Dementia and Geriatric Cognitive Disorders·A KerteszR Brashear
Jan 24, 2008·International Journal of Geriatric Psychiatry·Janine Diehl-SchmidAlexander Kurz
Sep 11, 2008·Psychopharmacology·Eleftheria TsaltasGeorge N Papadimitriou
Feb 11, 2009·The Journal of Clinical Psychiatry·Edward D HueyJordan Grafman
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Adam L BoxerBruce L Miller
Mar 18, 2010·Nature Reviews. Neurology·Alice S Chen-PlotkinJohn Q Trojanowski
May 8, 2010·Psychiatry and Clinical Neurosciences·Takemi KimuraJunichi Takamatsu
Sep 25, 2010·Lancet Neurology·Ian Ra MackenzieManuela Neumann
Dec 16, 2010·Journal of Alzheimer's Disease : JAD·Martine VercellettoUNKNOWN French research network on Frontotemporal dementia
May 4, 2011·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Maria da Glória PortugalJerson Laks
Aug 2, 2011·Frontiers in Neuroendocrinology·Nadine StriepensRené Hurlemann
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Aug 24, 2011·Brain : a Journal of Neurology·Sarah JessoElizabeth C Finger
Sep 1, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nathan HerrmannKrista L Lanctôt
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jun 22, 2012·International Psychogeriatrics·Sabine NunnemannJanine Diehl-Schmid
Aug 15, 2012·Acta Neuropathologica·Anne SiebenMarc Cruts
Aug 16, 2012·Alzheimer Disease and Associated Disorders·Julio C FurlanMorris Freedman
Aug 2, 2013·Journal of Geriatric Psychiatry and Neurology·Janine Diehl-SchmidBarbara Cramer
Aug 8, 2013·BMJ : British Medical Journal·Jason D WarrenMartin N Rossor
Oct 30, 2013·American Journal of Alzheimer's Disease and Other Dementias·Maria Nardell, Rajesh R Tampi
Apr 15, 2014·British Journal of Pharmacology·B Guardiola-LemaitreE Mocaër

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Jan 10, 2021·Alzheimer's Research & Therapy·Mélanie LeroyUNKNOWN Méotis network
Sep 14, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Raffaella MigliaccioRichard Levy
Feb 4, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Atsuko IkenouchiReiji Yoshimura
May 11, 2021·Frontiers in Psychiatry·Ruben MuñizJavier Olazarán

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