Abstract
High on-treatment platelet reactivity (HTPR) is the phenomenon wherein patients exhibit normal platelet activity in laboratory testing despite adequate adherence to anti-platelet treatment. We investigated the detection rates of Platelet Function Analyzer (PFA)-100 (Dade Behring AG, Düdingen, Switzerland) for drug-induced platelet dysfunction and analyzed potential contributors to HTPR with practical PFA-100 data over six years. We used data from 6,957 patients who underwent PFA-100 testing after receiving aspirin, clopidogrel, or non-steroidal anti-inflammatory drugs (NSAIDs). Of these, 6,163 patients were tested with only the collagen/epinephrine cartridge (Col/EPI) of PFA-100; 794 were tested with both Col/EPI and the collagen/ADP cartridge (Col/ADP). We calculated PFA-100 closure time (CT) for each drug and compared the clinical and laboratory characteristics of the patients with prolonged CTs and normal CTs (i.e., HTPR). In Col/EPI, 73.2% (365/499), 72.6% (390/537), and 55.3% (3,442/6,228) patients showed prolonged CTs for aspirin, clopidogrel, and NSAIDs, respectively. In Col/ADP, prolonged CTs were observed in 37.4% (34/91), 43.2% (35/81), and 29.6% (200/676) of patients receiving aspirin, clopidogrel, and NSAIDs, respec...Continue Reading
References
May 14, 1998·Seminars in Thrombosis and Hemostasis·E F MammenD J Nugent
Mar 10, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P HarrisonS J Machin
Nov 7, 2000·The American Journal of Medicine·C CatenaL A Sechi
Jun 6, 2002·British Journal of Clinical Pharmacology·D J W van KraaijE J Vollaard
Oct 31, 2002·Neoplasia : an International Journal for Oncology Research·Graham J CaineSean T Kehoe
Jan 16, 2003·Arthritis and Rheumatism·Colin Baigent, Carlo Patrono
Sep 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Marco Cattaneo
Oct 14, 2004·Anaesthesia·A M BlaicherK Hoerauf
Apr 6, 2005·Annals of Internal Medicine·Neil A GoldenbergMarilyn J Manco-Johnson
Apr 9, 2005·Stroke; a Journal of Cerebral Circulation·Paul HarrisonPeter M Rothwell
Oct 4, 2005·Journal of the American College of Cardiology·Andrew O MareeDesmond J Fitzgerald
Jun 3, 2006·BMJ : British Medical Journal·Patricia M KearneyCarlo Patrono
Sep 29, 2006·Anesthesiology·Seema AgarwalSusan Mallett
Dec 21, 2006·Nature Clinical Practice. Cardiovascular Medicine·Carlo Patrono, Bianca Rocca
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·M Cattaneo
Aug 29, 2007·Journal of Thrombosis and Haemostasis : JTH·R PanicciaD Prisco
Dec 21, 2007·The Korean journal of laboratory medicine·Young-Uk ChoChan-Jeoung Park
Oct 2, 2008·European Heart Journal·Marie LordkipanidzéJean G Diodati
Feb 14, 2009·Seminars in Thrombosis and Hemostasis·Emmanuel J Favaloro
Mar 17, 2009·Best Practice & Research. Clinical Haematology·Anna FalangaLaura Russo
Mar 17, 2010·Srpski arhiv za celokupno lekarstvo·Mojca Stegnar
Jul 31, 2010·Platelets·Sébastien ArméroLaurent Bonello
Oct 23, 2010·Pharmacology & Therapeutics·Hong-Guang XieShao-Liang Chen
Dec 7, 2010·Cardiovascular Therapeutics·Kyung Woo ParkHyo-Soo Kim
Dec 21, 2010·Nature Medicine·Heleen J BoumanDirk Taubert
Feb 16, 2011·British Journal of Clinical Pharmacology·Timothy D WarnerCarl Whatling
Feb 22, 2011·Pharmacogenomics·Bas J M PetersVera H M Deneer
Apr 27, 2011·British Journal of Clinical Pharmacology·Yanushi Dullewe Wijeyeratne, Stan Heptinstall
Mar 7, 2012·Vascular Health and Risk Management·Dan J Fintel
Jan 3, 2013·Journal of Thrombosis and Haemostasis : JTH·A FalangaA Vignoli
Jul 31, 2013·Bioscience Reports·Luize G Lima, Robson Q Monteiro
Jan 2, 2015·Annals of Laboratory Medicine·Jung-Ah KimHyun Kyung Kim
Aug 25, 2015·Surgery·Ashley BartelsSalman Ahmad
Oct 21, 2016·Journal of Thrombosis and Haemostasis : JTH·I MahéS Noble
Oct 22, 2016·Thrombosis Journal·Pantep Angchaisuksiri