Effectiveness of platelet-rich fibrin matrix treated with silver nanoparticles in fracture healing in rabbit model

Veterinary World
Serwa Ibrahim SalihAhmed N Abedsalih

Abstract

The current study was conducted to evaluate the effect of platelet-rich fibrin matrix (PRFM) treated with silver nanoparticles (AgNPs) on enhancing the healing of the experimentally induced bone gap in a rabbit model. Twenty healthy male local rabbits aged between 6 and 8 months, their weights between 1.5 and 2 kg were used in this study and divided randomly into four equal groups, under general anesthesia (1 cm), bone gap was induced in the tibia bone to create a critical bone defect and leave it without any treatment in the first group (control group). While in the second group the bone gap was filled with PRFM; in the third group, the gap was filled with 0.3 ml AgNPs; and in the fourth group, the gap was filled with PRFM treated with AgNPs. There was no infection at the operation site in all experimental animals, and the radiograph images showed periosteal and endosteal reaction; the gaps were bridged faster in the fourth group as compared with the other groups. The histological examination showed lamellar bone with haversian canal completely filled the fracture gap and contact with old bone in the fourth group as compared to other groups. Using a combination of PRFM and single nucleotide polymorphisms together gave better a...Continue Reading

References

Jan 1, 1989·Lasers in Surgery and Medicine·J S NelsonM W Berns
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D DanonG S Roth
Dec 14, 2002·Science·Yugang Sun, Younan Xia
Jul 23, 2003·The Journal of Biological Chemistry·Stephen E GirardinDominique Mengin-Lecreulx
Sep 13, 2003·Clinical Oral Implants Research·Ronald E JungFranz E Weber
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Lakshmi S Nair, Cato T Laurencin
Apr 29, 2008·Bioprocess and Biosystems Engineering·Jae Yong Song, Beom Soo Kim
Oct 24, 2008·Advances in Colloid and Interface Science·Virender K SharmaYekaterina Lin
May 20, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Volker L W GasslingJörg Wiltfang
Jun 18, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Tomoo OdaMinoru Ueda
Mar 13, 2010·Current Pharmaceutical Design·Mahesh Kumar TeliG K Rajanikant
Aug 28, 2012·International Journal of Nanomedicine·Andrea TautzenbergerAnita Ignatius
Aug 19, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Ruizhong ZhangKenneth K Y Wong

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BETA
surface plasmon resonance

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