Effectiveness of Platelet-Rich Plasma to Enhance Healing of Diabetic Foot Ulcers in Patients With Concomitant Peripheral Arterial Disease and Critical Limb Ischemia

The International Journal of Lower Extremity Wounds
Nikolaos KontopodisChristos Ioannou

Abstract

We sought to investigate the effect of autologous platelet-rich plasma (PRP) on the healing rate of diabetic foot ulcers in patients with diabetes and concomitant peripheral arterial disease (PAD). Diabetic patients with foot ulceration presenting with PAD who were treated with local growth factors in a single center, during a 24-month period from May 2009 to April 2011, were retrospectively reviewed. Based on the severity of PAD, subjects were divided into groups A (Fontaine classification stages I, IIa, and IIb) and B (Fontaine classification stages III and IV), with those included in the latter being considered to suffer from critical limb ischemia (CLI). End points of the analysis were clinical improvement, limb salvage, and amputation rate. Outcome was compared between groups A and B. Overall, 72 patients were evaluated, 30 with CLI. Ulcer area reduction >50% was observed in 58/72 patients while reduction >90% was achieved in 52/72 patients. There were 14 (19%) major and minor amputations, whereas the limb salvage rate was 89%. This variable was significantly different between groups A and B (100% vs. 73%, P < .001), as is rate of reduction in ulcer area >90% (83% vs. 56%, P = .02). Reduction of ulcer area >50% was observe...Continue Reading

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Citations

May 29, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Frédéric PicardJean-Paul Meningaud
Nov 28, 2013·Medical Hypotheses·Itay E GabbayUri Gabbay
Jun 15, 2017·Tissue Engineering. Part a·Michael StolleAthanasia Warnecke
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Jan 30, 2018·Annals of the New York Academy of Sciences·Estelle Everett, Nestoras Mathioudakis
Jul 20, 2019·Acta Radiologica·Elias KehagiasDimitrios Tsetis
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Nov 20, 2019·The Indian Journal of Radiology & Imaging·Arun Sharma
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou
Apr 21, 2021·Regenerative Medicine·Damien P Kuffler
Nov 16, 2021·Archives of Sexual Behavior·Emily ManinJasmine Abdulcadir

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Methods Mentioned

BETA
amputation
amputations

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