Effectiveness of Prevention Strategies for Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis

Annals of Internal Medicine
Rathan M SubramaniamEric B Bass

Abstract

N-acetylcysteine, sodium bicarbonate, statins, and ascorbic acid have been studied for reducing contrast-induced nephropathy (CIN). To evaluate the comparative effectiveness of interventions to reduce CIN in adults receiving contrast media. MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, and Scopus databases through June 2015. Risk of bias and overall strength of evidence (SOE) of studies were assessed. Randomized, controlled trials of N-acetylcysteine, sodium bicarbonate, statins, or ascorbic acid that used intravenous (IV) or intra-arterial contrast media and defined CIN with enough data for meta-analysis. Two reviewers independently extracted data and assessed study quality. Low-dose N-acetylcysteine plus IV saline compared with IV saline (risk ratio [RR], 0.75 [95% CI, 0.63 to 0.89]; low SOE), N-acetylcysteine plus IV saline compared with IV saline in patients receiving low-osmolar contrast media (RR, 0.69 [CI, 0.58 to 0.84]; moderate SOE), and statins plus N-acetylcysteine plus IV saline versus N-acetylcysteine plus IV saline (RR, 0.52 [CI, 0.29 to 0.93]; low SOE) had clinically important and statistically significant benefits. The following 3 comparisons suggested a clinically important difference that was not stat...Continue Reading

Citations

Dec 13, 2018·American Journal of Physiology. Renal Physiology·Joshua L Rein, Steven G Coca
Jul 22, 2019·Physiological Reports·Weslei V de LimaWaldemar S Almeida
Nov 15, 2019·Current Opinion in Nephrology and Hypertension·Swapnil Hiremath, Juan Carlos Q Velez
Oct 18, 2016·Current Opinion in Nephrology and Hypertension·Jill VanmassenhoveNorbert Lameire
Dec 21, 2017·Current Opinion in Nephrology and Hypertension·Joe AounBertrand L Jaber
Jan 5, 2017·Circulation. Cardiovascular Interventions·Richard Solomon, Harold L Dauerman
Mar 24, 2018·Current Treatment Options in Cardiovascular Medicine·Arash Ehteshami Afshar, Puja B Parikh
May 29, 2018·Journal of Nephrology·Valentina PistolesiEnrico Fiaccadori
Sep 29, 2018·Canadian Journal of Kidney Health and Disease·Johnny W HuangSwapnil Hiremath
Nov 12, 2019·Japanese Journal of Radiology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Oct 21, 2016·The British Journal of Radiology·Martine Ann HarrisRuth Clarke
Jan 24, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Richard Sinert
Nov 12, 2019·Clinical and Experimental Nephrology·Yoshitaka IsakaUNKNOWN Japanese Society of Nephrology, Japan Radiological Society, and Japanese Circulation Society Joint Working Group
Aug 24, 2018·Nature Reviews. Nephrology·Eric A J HosteLakhmir S Chawla
Apr 11, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yongxing XuZhaoyan Gu
Jan 10, 2019·Systematic Reviews·Francesca WuytackDeclan Devane
Oct 4, 2016·European Journal of Clinical Pharmacology·Xue-Biao WeiYuan-Hui Liu
Nov 14, 2017·The New England Journal of Medicine·Steven D WeisbordUNKNOWN PRESERVE Trial Group
Nov 4, 2017·World Journal of Radiology·Mohamed R Nouh, Mohamed A El-Shazly
Oct 6, 2020·Phytotherapy Research : PTR·Motahareh Boozari, Hossein Hosseinzadeh
Feb 9, 2021·Néphrologie & thérapeutique·Louis de LaforcadeUNKNOWN Commission Néphrologie Clinique de la Société Francophone de Néphrologie, Dialyse et Transplantation
Jul 27, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Pratheema Ramachandran, Devachandran Jayakumar
Apr 23, 2021·Seminars in Interventional Radiology·Ali KordCharles E Ray
Nov 12, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka IsakaUNKNOWN Japanese Circulation Society Joint Working Group

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