Effectiveness of Probiotics in Children With Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review

Journal of Clinical Gastroenterology
Carrie A M WeghMerit M Tabbers

Abstract

The objective of this study was to investigate the effect of probiotics on functional abdominal pain disorders (FAPD) and functional constipation (FC). A systematic review was conducted, searching PubMed and Cochrane databases from inception to January 2018 for randomized controlled trials (RCTs) investigating the efficacy of probiotics in children aged 4 to 18 years with FAPD or children aged 0 to 18 years with FC. A total of 657 citations were identified. Finally, 11 RCTs for FAPD and 6 RCTs for FC were included. Some evidence exists for Lactobacillus rhamnosus GG (n=3) in reducing frequency and intensity of abdominal pain in children with irritable bowel syndrome. There is no evidence to recommend L. reuteri DSM 17938 (n=5), a mix of Bifidobacterium infantis, Bifidobacterium breve and Bifidobacterium longum (n=1), Bifidobacterium lactis (n=1) or VSL#3 (n=1) for children with FAPD. No evidence exists to support the use of Lactobacillus casei rhamnosus LCR35 (n=1), B. lactis DN173 010 (n=1), B. longum (n=1), L. reuteri DSM 17938 (n=1), a mix of B. infantis, B. breve and B. longum (n=1), or Protexin mix (n=1) for children with FC. In general, studies had an unclear or high risk of bias. Insufficient evidence exists for the use ...Continue Reading

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Citations

Mar 11, 2020·Archives of Disease in Childhood·Edward Thomas AndrewsMark P Tighe
Sep 19, 2019·Paediatrics & Child Health·Fang Chao Linda DingSunita Vohra
Dec 7, 2018·Nutrients·Anna PärttyMarko Kalliomäki
Feb 9, 2021·Frontiers in Pediatrics·David Avelar RodriguezErick Manuel Toro Monjaraz
Nov 7, 2020·Nature Reviews. Disease Primers·Nikhil ThaparPaul Enck

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