Abstract
Quetiapine is an atypical antipsychotic that is commonly used in the Intensive Care Unit (ICU). The utility of quetiapine as a sedative adjunct has not yet been evaluated, but has been described previously in studies evaluating quetiapine for delirium or delirium prophylaxis. To determine if adjunctive use of quetiapine reduces sedative dosage requirements among mechanically ventilated adults without delirium. This retrospective intrapatient comparator study included all mechanically ventilated adults admitted to a medical ICU who received quetiapine between July 1, 2013, and July 1, 2018. The primary outcome was the change in sedative dosage requirements over 24 hours following quetiapine initiation. Secondary outcomes included change in sedative dosage requirements 48 hours postquetiapine initiation, opioid dosage requirements 24 hours postquetiapine initiation, percent time at goal for both pain and sedation scores, depth of sedation, and QTc. A total of 57 patients were included in the study cohort. There was no significant difference in 24-hour cumulative doses of propofol (P = 0.10), dexmedetomidine (P = 0.14), or benzodiazepines (P = 0.14). During the 48-hour treatment period, there was a significant increase in dexmedet...Continue Reading
References
Aug 17, 2001·Anesthesiology·J BarrE Geller
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·Curtis N SesslerR K Elswick
Feb 15, 2007·The Annals of Pharmacotherapy·Asad E PatanwalaBrian L Erstad
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Pratik P PandharipandeE Wesley Ely
Jan 15, 2008·Lancet·Timothy D GirardE Wesley Ely
Feb 4, 2009·JAMA : the Journal of the American Medical Association·Richard R RikerUNKNOWN SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group
Jul 16, 2009·Critical Care Medicine·Miriam M TreggiariNoel S Weiss
Nov 17, 2009·Critical Care Medicine·John W DevlinErik Garpestad
Jan 23, 2010·Critical Care Medicine·Timothy D GirardUNKNOWN MIND Trial Investigators
Jun 4, 2010·Critical Care Medicine·John W DevlinRichard R Riker
Mar 23, 2012·JAMA : the Journal of the American Medical Association·Stephan M JakobUNKNOWN Dexmedetomidine for Long-Term Sedation Investigators
May 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Joshua T SwanKrista L Turner
Jul 19, 2013·Critical Care Medicine·Yahya ShehabiUNKNOWN Australian and New Zealand Intensive Care Society Clinical Trials Group
Oct 18, 2013·Critical Care Medicine·Gilles L FraserFrederick A Spencer
Jan 31, 2014·The New England Journal of Medicine·Michael C Reade, Simon Finfer
Apr 19, 2015·Journal of Critical Care·Bridgette L KramKelli R Brooks
Jul 7, 2015·Psychopharmacology·Hirotoshi SatoKazuhiko Yanai
Sep 19, 2015·Journal of Critical Care·A Shaun RoweVictoria W Reynolds
Nov 28, 2015·Journal of Intensive Care·Kimberly J TerryPaul M Szumita
Jan 29, 2016·Journal of Critical Care·John MarshallJennifer P Stevens
Jan 19, 2017·Revista Brasileira de terapia intensiva·Thiago Miranda Lopes de AlmeidaFlávia Ribeiro Machado
Mar 27, 2018·World Journal of Emergency Medicine·Saeed MahmoodHassan Al-Thani
Aug 17, 2018·Critical Care Medicine·John W DevlinWaleed Alhazzani
Oct 23, 2018·The New England Journal of Medicine·Timothy D GirardUNKNOWN MIND-USA Investigators
Sep 24, 2019·The Annals of Pharmacotherapy·Mitulkumar PatelJohn Papadopoulos
Mar 28, 2020·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Matthew P AbrahamJames C McMillen