Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions

Medicines
Jacob M VigilBranden Hall

Abstract

Background: We use a mobile software application (app) to measure for the first time, which fundamental characteristics of raw, natural medical Cannabis flower are associated with changes in perceived insomnia under naturalistic conditions. Methods: Four hundred and nine people with a specified condition of insomnia completed 1056 medical cannabis administration sessions using the Releaf AppTM educational software during which they recorded real-time ratings of self-perceived insomnia severity levels prior to and following consumption, experienced side effects, and product characteristics, including combustion method, cannabis subtypes, and/or major cannabinoid contents of cannabis consumed. Within-user effects of different flower characteristics were modeled using a fixed effects panel regression approach with standard errors clustered at the user level. Results: Releaf AppTM users showed an average symptom severity reduction of -4.5 points on a 0⁻10 point visual analogue scale (SD = 2.7, d = 2.10, p < 0.001). Use of pipes and vaporizers was associated with greater symptom relief and more positive and context-specific side effects as compared to the use of joints, while vaporization was also associated with lower negative effe...Continue Reading

References

Apr 1, 1975·Clinical Pharmacology and Therapeutics·I FeinbergJ March
Feb 24, 2001·Human & Experimental Toxicology·D RadovanovicH Kupferschmidt
Jan 18, 2003·Sleep Medicine Reviews·Maurice M Ohayon
May 1, 2004·Journal of Clinical Psychopharmacology·Anthony N NicholsonPhilip J Robson
Jul 22, 2006·Forensic Science International : Synergy·Fritz PragstAbdulsallam Bakdash
Dec 6, 2006·The American Journal of Medicine·Stephen BentWolf Mehling
Nov 3, 2010·Annual Review of Pharmacology and Toxicology·Thomas E Scammell, Christopher J Winrow
Jan 24, 2012·Lancet·Charles M Morin, Ruth Benca
Jul 18, 2012·Journal of Psychiatric Research·Jason G EllisCélyne H Bastien
Jan 15, 2014·Drug and Alcohol Dependence·Marcel O Bonn-MillerRyan Vandrey
Mar 22, 2014·BMJ : British Medical Journal·Scott WeichMartin Frisher
Apr 15, 2014·Sleep Medicine Reviews·Peter J GatesJan Copeland
Jan 27, 2015·JAMA Internal Medicine·Shelly L GrayEric B Larson
Feb 24, 2015·Bioorganic & Medicinal Chemistry·Sumner Burstein
Jun 24, 2015·JAMA : the Journal of the American Medical Association·Penny F WhitingJos Kleijnen
Jul 8, 2015·Addictive Behaviors·Katherine A BelendiukMarcel O Bonn-Miller
Aug 19, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Seockhoon ChungSuyeon Lee
Jan 23, 2016·British Journal of Pharmacology·África FloresFernando Berrendero
Jun 2, 2016·The Journal of Clinical Psychiatry·Cynthia A FontanellaMark Hurst
Jun 4, 2016·Science·Sarah See Stith, Jacob Miguel Vigil
Jul 8, 2016·Health Affairs·Ashley C Bradford, W David Bradford
Mar 30, 2017·Current Psychiatry Reports·Kimberly A BabsonDanielle Morabito
Apr 5, 2017·Journal of Psychopharmacology·Brian J PiperAlexander T Abess
Jun 27, 2017·Sleep Medicine Reviews·Fiona AuldRenata L Riha
Sep 14, 2017·Journal of the American Medical Directors Association·Sarah S StithAnthony P Reeve
Nov 9, 2017·JAMA : the Journal of the American Medical Association·Marcel O Bonn-MillerRyan Vandrey
Feb 24, 2018·Cancer Medicine·Paweł ŚledzińskiAgnieszka Nowak

❮ Previous
Next ❯

Citations

Feb 26, 2019·Scientific Reports·Sarah S StithBranden Hall
Sep 15, 2019·Complementary Therapies in Medicine·Xiaoxue LiBranden Hall
Aug 15, 2019·Neurotoxicology·Stefania BonaccorsoFabrizio Schifano
Mar 7, 2021·Drug and Alcohol Dependence·Ekaterina V FedorovaStephen E Lankenau
Feb 23, 2021·Cannabis and Cannabinoid Research·Saoirse E O'SullivanSteven R Laviolette
Jul 12, 2020·Current Opinion in Psychology·Irene BraithwaiteGiles Newton-Howes
Oct 28, 2021·Journal of Medical Internet Research·Nirushi KuhathasanBenicio N Frey

❮ Previous
Next ❯

Methods Mentioned

BETA
two hybrid

Software Mentioned

Releaf
Releaf App
Releaf App TM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.