Effectiveness of Resin-Based Sealants with and without Fluoride Placed in a High Caries Risk Population: Multicentric 2-Year Randomized Clinical Trial

Caries Research
Michèle Muller-BollaAna Miriam Velly

Abstract

A split-mouth randomized clinical trial was carried out to assess the effectiveness of sealants in preventing carious ICDAS (International Caries Detection and Assessment System) 3-6 lesions within a 2-year follow-up. We evaluated the effectiveness of 2 types of resin-based sealants, with and without fluoride, their retention rates, and the caries risk factors related to their outcomes. The study included 663 tooth pairs in 400 children (aged 5-15 years) considered to be at high individual caries risk (ICR) and presenting permanent molars free of caries or affected by ICDAS 1-2 lesions. In the first randomization, molars were either randomized to the treatment group receiving a dental sealant or the control group (nontreatment), and in the second randomization the sealant material to be used in the intervention group was selected. Uni- and multivariate Cox proportional hazard models were employed. At the 2-year follow-up, 483 tooth pairs were assessed: sealed molars had 83% (adjusted HR = 0.17; 95% CI: 0.15-0.20) less risk of developing ICDAS 3-6 lesions than molars without sealant. The magnitude of the protective effect was lower among teeth with ICDAS 1-2 lesions or with occlusal deep fissures than without. If the total reten...Continue Reading

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Citations

Feb 15, 2020·Clinical and Experimental Dental Research·Lenka Likar OstrcAlenka Pavlič
May 24, 2019·Scientific Reports·Fabio Rocha BohnsFabricio Mezzomo Collares
Oct 31, 2020·International Dental Journal·Ilze MaldupaEgita Senakola
Dec 31, 2020·European Journal of Oral Sciences·Olivier ChabadelEstelle Moulis
Aug 14, 2020·Academic Pediatrics·Lydie A Lebrun-HarrisMichael D Kogan
Nov 22, 2020·International Journal of Paediatric Dentistry·Michèle Muller-BollaSophie Doméjean
May 25, 2021·International Dental Journal·Ilze MaldupaEgita Senakola
Sep 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Nima MotallaeiAlireza Yazdanian

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