Effectiveness of Rotarix ® vaccine in Africa in the first decade of progressive introduction, 2009-2019:  systematic review and meta-analysis.

Wellcome Open Research
Nickson MurungaCharles N Agoti

Abstract

Background: Randomized controlled trials of licensed oral rotavirus group A (RVA) vaccines, indicated lower efficacy in developing countries compared to developed countries. We investigated the pooled effectiveness of Rotarix ® in Africa in 2019, a decade since progressive introduction began in 2009. Methods: A systematic search was conducted in PubMed to identify studies that investigated the effectiveness of routine RVA vaccination in an African country between 2009 and 2019. A meta-analysis was undertaken to estimate pooled effectiveness of the full-dose versus partial-dose of Rotarix ® (RV1) vaccine and in different age groups. Pooled odds ratios were estimated using random effects model and the risk of bias assessed using Newcastle-Ottawa scale. The quality of the evidence was assessed using GRADE. Results: By December 2019, 39 (72%) countries in Africa had introduced RVA vaccination, of which 34 were using RV1. Thirteen eligible studies from eight countries were included in meta-analysis for vaccine effectiveness (VE) of RVA by vaccine dosage (full or partial) and age categories. Pooled RV1 VE against RVA associated hospitalizations was 44% (95% confidence interval (CI) 28-57%) for partial dose versus 58% (95% CI 50-65%) ...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
May 18, 2010·Vaccine·Carlos RodrigoCarlo Giaquinto
Jul 14, 2010·Human Vaccines·Victoria JiangManish M Patel
Jul 24, 2012·Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen·Gero LangerHolger Schünemann
Aug 14, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T Vesikari
Jul 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacqueline E Tate, Umesh D Parashar
Apr 29, 2015·Vaccine·Lúcia Helena de OliveiraJosé Paulo Gagliardi Leite
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul A GastañaduyDavid M Goldfarb
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura K BeresRoma Chilengi
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George ArmahBen Lopman
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naor Bar-ZeevUNKNOWN Vaccine Effectiveness and Disease Surveillance Programme, Malawi (VACSURV) Consortium
Jul 28, 2016·Einstein·Adriana Luchs, Maria do Carmo Sampaio Tavares Timenetsky
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James A Platts-MillsEric R Houpt
Sep 21, 2017·F1000Research·Miguel O'Ryan
Dec 1, 2017·The Pediatric Infectious Disease Journal·Margaret MokomaneDavid M Goldfarb
Dec 28, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilda A MujuruJacqueline E Tate
Jul 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sammy KhagayiJennifer R Verani

❮ Previous
Next ❯

Citations

Sep 7, 2021·Expert Opinion on Biological Therapy·Jordan E CatesUmesh Parashar

❮ Previous
Next ❯

Software Mentioned

Excel
GRADE
STATA
VIEW

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Pediatric Infectious Disease Journal
Rachel M BurkeUmesh D Parashar
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Paul A GastañaduyDavid M Goldfarb
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
George ArmahBen Lopman
© 2021 Meta ULC. All rights reserved