PMID: 26327703Sep 4, 2015Paper

Effectiveness of Sodium Polystyrene Sulfonate for Short-Term Treatment of Hyperkalemia

The Canadian Journal of Hospital Pharmacy
Josh BatterinkTara Cessford

Abstract

Sodium polystyrene sulfonate (SPS) is a potassium-binding resin that is commonly used to treat mild hyperkalemia. However, there is limited evidence supporting its effectiveness in the short-term management of hyperkalemia. To determine whether SPS is effective in reducing serum potassium in general medical patients after a single oral dose. A retrospective observational study was conducted for patients admitted to the internal medicine service of a tertiary care hospital between January 2011 and May 2012 with documentation of a serum potassium level between 5.0 and 5.9 mmol/L during the hospital stay. Patients eligible for inclusion were adults without chronic or acute renal failure or recent changes in medication or diet that would affect serum potassium level. Propensity score matching was performed to minimize differences between the control group (no treatment) and the treatment group (treatment with oral SPS). Follow-up serum potassium levels (at 6-24 h) were compared with index potassium levels. A total of 138 patients met the inclusion criteria, 72 in the control group and 66 in the treatment group. For most patients in the treatment group, the dose was 15 or 30 g of SPS orally. The difference between the control and tr...Continue Reading

Citations

Jan 31, 2018·International Journal of Clinical Practice·Eirini PalakaSusan Grandy
Jul 31, 2021·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Jürgen L HolleckCraig G Gunderson

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