PMID: 7018430Jul 1, 1981Paper

Effectiveness of steroid/antibiotic treatment in primates administered LD100 Escherichia coli

Annals of Surgery
L B HinshawM F Wilson

Abstract

Early aggressive therapy with maintenance infusions of methylprednisolone sodium succinate and gentamicin sulfate significantly increases the probability for survival of baboons given LD100 Escherichia coli. The present study was designed to determine if baboons would recover when initiation of treatment was delayed until they had sustained E. coli-induced systemic hypotension for a period of approximately three hours. Sixteen adult baboons were each administered a two-hour infusion of LD100 E. coli. All eight untreated animals died within 42 hours. Five of the eight baboons treated after approximately three hours of hypotension with methylprednisolone sodium succinate and gentamicin sulfate survived. Treated animals had significantly higher blood glucose and insulin levels and lower blood urea nitrogen concentrations than baboons receiving E. coli alone. E. coli blood concentrations were lower in the treated than in the untreated baboon group by the sixth hour (less than 0.02). Heart rates increased in all animals but were not as high in the treated baboons. Both groups experienced similar decreases in mean systemic arterial pressure, PCO2, base excess, leukocyte, lymphocyte, and platelet concentrations, and increases in creat...Continue Reading

References

Apr 1, 1978·American Journal of Surgery·G H ClowesR Goodfellow
Sep 1, 1976·Annals of Surgery·W Schumer
Feb 1, 1980·The Journal of Surgical Research·L B HinshawG L White

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Citations

Jan 1, 1984·Intensive Care Medicine·W J Sibbald
Mar 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M E SoulsbyR C Bone
Nov 16, 2004·Critical Care Medicine·Didier Keh, Charles L Sprung
Apr 1, 1991·Inflammation·N J JansenC R Wildevuur
Sep 6, 2014·Nature Reviews. Drug Discovery·Mitchell P Fink, H Shaw Warren
Nov 4, 2000·Expert Opinion on Investigational Drugs·B D Freeman, C Natanson
Jul 1, 1984·Current Problems in Surgery·T HauM I Aeder
Sep 12, 2013·Virulence·Mitchell P Fink
Feb 21, 1985·The New England Journal of Medicine·A N Lieberman, M Goldstein
Dec 24, 2005·Shock·Heinz Redl, Soheyl Bahrami
Jan 1, 1987·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E FosseA O Aasen
Jan 30, 2003·Annals of Medicine·Marc J Schultz, Tom van der Poll
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Feb 13, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P MinneciP Q Eichacker
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Oct 1, 1987·Infection and Immunity·D T GolenbockR A Proctor
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