Effectiveness of submicronized chitosan-coated liposomes in oral absorption of indomethacin

Journal of Liposome Research
Hikaru SugiharaHirofumi Takeuchi

Abstract

The plasma profile of indomethacin (IMC) after oral administration of IMC-loaded submicronized chitosan-coated liposomes (ssCS-Lip) was evaluated to reveal the effectiveness of the mucoadhesive function for improving the absorption of this poorly absorbable drug. The stomach and small intestine were removed from rats after 1, 2, and 4 hours of oral administration of submicron-sized liposomes (ssLip) or ssCS-Lip containing fluorescent dye, and the retentive properties were confirmed by measuring the amount of dye in each part of the gastrointestinal (GI) tract. Results showed that ssCS-Lip tended to be better retained in the upper part of the GI tract, compared with ssLip, at 1, 2, and 4 hours after administration, and was significantly better retained in the small intestine at 4 hours. The plasma profile and bioavailability of IMC after oral administration of both types of liposomes were improved, compared with oral administration of IMC solution. The maximum residence time of ssCS-Lip was significantly longer than those of ssLip. The extended plasma profile of ssCS-Lip was attributed to its prolonged retention in the upper region of the GI tract, and its delayed migration to the lower part of the intestine, the neutral pH of w...Continue Reading

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Citations

Apr 24, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hyo-Kyung HanDong Hoon Ha
Nov 20, 2015·Therapeutic Delivery·Wei WuJianping Qi
Jul 11, 2013·Colloids and Surfaces. B, Biointerfaces·Xiang Yuan XiongYan Chun Gong
Apr 14, 2016·Nanomedicine·Thanh Xuan NguyenQun Wang
Jun 15, 2014·International Journal of Pharmaceutics·May Wenche JøraholmenNataša Skalko-Basnet
May 7, 2016·Biological & Pharmaceutical Bulletin·Yuuki IshidaNaoto Oku
Oct 31, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Omar Mertins, Rumiana Dimova
Jan 1, 2012·Journal of Functional Biomaterials·Susana RodriguesAna Grenha
Oct 6, 2012·Chemical & Pharmaceutical Bulletin·Hikaru SugiharaHirofumi Takeuchi
Nov 24, 2017·Drug Development and Industrial Pharmacy·Kohei TaharaHirofumi Takeuchi
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahmoud HasanMichel Linder
Aug 4, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hirofumi Takeuchi
Nov 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Thanh Xuan NguyenGuang Yang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Gliszczyńska, Marta Nowaczyk
Oct 2, 2021·AAPS PharmSciTech·Mumuni SumailaYahya E Choonara

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