Abstract
In Japan, biologic therapy was initiated for patients with severe asthma in 2009. In recent years, four biologics with different mechanisms of action have become available in the clinical setting. However, the efficacy of switching between biologics remains uncertain. To elucidate the efficacy of switching between biologics, 97 patients were enrolled who had received any biologic therapy for severe asthma at Jikei University Hospital, Tokyo, Japan, from July 2009 to December 2020. We retrospectively examined the patient characteristics, biomarkers, pulmonary function test results, selected biologics, and efficacy. Thirty-one males and 66 females received any biologics. The mean age was 53.3 years at the initiation of biologic therapy. Initially, 33, 41, 15 and eight patients received omalizumab, mepolizumab, benralizumab, and dupilumab, respectively. Among three representative indicators for biologics administration, the peripheral blood eosinophil count, serum IgE levels and fractional exhaled nitric oxide, 64% of the patients had two indicators, and 28% had three indicators. Thirty-four patients (35%) switched from the initial biologic to another, and the reasons for switching included persistent asthmatic symptoms (n=22), sc...Continue Reading
References
Feb 1, 2005·Allergy·M HumbertK Surrey
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Sep 22, 2009·The Journal of Allergy and Clinical Immunology·Michael SchatzPriti Jhingran
May 20, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Yuma FukutomiKazuo Akiyama
Aug 21, 2012·Lancet·Ian D PavordPascal Chanez
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Nicola A HananiaWilliam Busse
Sep 10, 2014·The New England Journal of Medicine·Hector G OrtegaUNKNOWN MENSA Investigators
Sep 10, 2014·The New England Journal of Medicine·Elisabeth H BelUNKNOWN SIRIUS Investigators
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Pieter-Paul W HekkingElisabeth H Bel
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Jennifer NamazyElizabeth B Andrews
Apr 19, 2016·Allergy·A MagnanH Ortega
Aug 25, 2016·American Journal of Respiratory and Critical Care Medicine·Loren C DenlingerUNKNOWN National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators
Sep 10, 2016·Lancet·J Mark FitzGeraldUNKNOWN CALIMA study investigators
Sep 10, 2016·Lancet·Eugene R BleeckerUNKNOWN SIROCCO study investigators
Feb 1, 2017·Respiratory Medicine·Sarah M CockleJenny Willson
Feb 16, 2017·Allergology International : Official Journal of the Japanese Society of Allergology·Masakazu IchinoseUNKNOWN Japanese Society of Allergology
May 23, 2017·The New England Journal of Medicine·Parameswaran NairUNKNOWN ZONDA Trial Investigators
Aug 15, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Masako MatsusakaTomoko Betsuyaku
Sep 19, 2017·The Lancet. Respiratory Medicine·J Mark FitzGeraldMitchell Goldman
Feb 8, 2018·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bradley E ChippsMitchell Goldman
Mar 14, 2018·ERJ Open Research·Eleftherios ZervasMina Gaga
Mar 17, 2018·The European Respiratory Journal·Marc HumbertUNKNOWN STELLAIR investigators
May 22, 2018·The New England Journal of Medicine·Mario CastroAriel Teper
May 22, 2018·The New England Journal of Medicine·Klaus F RabeAriel Teper
Sep 1, 2018·Lung·Imran H IftikharDavid Amrol
Sep 12, 2018·The Journal of Allergy and Clinical Immunology·William BusseNecdet B Gunsoy
Oct 13, 2018·The European Respiratory Journal·Arnaud BourdinXiao Xu
May 3, 2019·Allergy·Kenneth R ChapmanMark C Liu
Jun 21, 2019·Respiratory Medicine·Marc HumbertNamhee Kwon
Sep 24, 2019·Lancet·Claus BachertLeda P Mannent
Oct 14, 2019·BMC Pulmonary Medicine·Takanori NumataKazuyoshi Kuwano
Jan 26, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Masako ToYasuo To
Apr 11, 2020·Chest·Joanne E KavanaghDavid J Jackson
Jun 3, 2020·Therapeutic Advances in Respiratory Disease·Giovanna Elisiana CarpagnanoMaria Pia Foschino Barbaro
Aug 5, 2020·BMC Pulmonary Medicine·Takanori NumataKazuyoshi Kuwano
Aug 14, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Yu Yu HanGang Wang
Sep 28, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Carlo MümmlerKatrin Milger
Nov 19, 2020·Journal of Asthma and Allergy·Nora DrickHendrik Suhling