Effectiveness of systemic antimicrobial therapy in combination with scaling and root planing in the treatment of periodontitis: a systematic review

The Journal of the American Dental Association
Pablo Garcia CanasPeter M Loomer

Abstract

The use of systemic antibiotics in conjunction with scaling and root planing (SRP) may improve the clinical outcome and even could be essential for a successful treatment of periodontitis. However, the effectiveness and clinical safety of this combination of therapy remain unclear. The authors of this study reviewed the available literature related to this hypothesis, evaluating the effectiveness of the use of systemic antimicrobials in combination with SRP versus SRP alone in the treatment of chronic periodontitis (CP) or aggressive periodontitis (AgP). The authors used 3 electronic databases and hand searched articles published from April 2001 through October 2013 in selected journals. The authors selected clinical trials with a minimum of 6 months follow-up during which patients with either CP or AgP had been treated with systemic antibiotics plus SRP in comparison with SRP alone or with placebo. The authors analyzed the gain in clinical attachment level (CAL), reduction in probing pocket depth (PPD), reduction in bleeding on probing (BOP), and patient-related variables (that is, adverse effects). After the selection process, the authors included 23 clinical trials in this review. Assessment of the quality of the studies rev...Continue Reading

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Citations

Jan 8, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F S MartelliE Medico
Jul 18, 2015·Photodiagnosis and Photodynamic Therapy·Fahim VohraFawad Javed
Nov 20, 2016·Oral Diseases·P Holmstrup, B Klausen
Oct 31, 2018·Clinical Oral Investigations·B PretzlY Jockel-Schneider
Jun 18, 2020·International Journal of Environmental Research and Public Health·Aymeric CourvalJean-Luc Davideau
Dec 5, 2019·Brazilian Dental Journal·Camila Camarinha da Silva CirinoAntônio Wilson Sallum
Oct 13, 2020·Journal of International Society of Preventive & Community Dentistry·Sudhir Rama VarmaSalim Abu Fanas
Nov 20, 2020·Clinical and Experimental Dental Research·Elisabetta PolizziGiulia Tetè

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