Effectiveness of the pentavalent rotavirus vaccine in preventing gastroenteritis in the United States

Pediatrics
Florence T WangJohn D Seeger

Abstract

In clinical trials, the pentavalent rotavirus vaccine (RV5) was efficacious in preventing severe rotavirus gastroenteritis (RGE) and related health care encounters. We assessed the vaccine effectiveness (VE) of RV5 among US infants during the first 2 rotavirus seasons after vaccine licensure. Using a large, national, health insurance claim database, we monitored 2 cohorts of infants (infants who received 3 doses of RV5 and a concurrent group of infants who received 3 doses of diphtheria-tetanus-acellular pertussis vaccine but did not receive RV5) through the 2007 and 2008 rotavirus seasons (January 1 to May 31), to identify cases of RGE and all-cause acute gastroenteritis (AGE) resulting in medical care encounters. We estimated the VE in reducing hospitalizations, emergency department (ED) and physician office visits, and health care resource utilization, as measured by days and costs of hospitalizations and ED visits. A total of 33 140 RV5-vaccinated infants and 26 167 infants in the concurrent diphtheria-tetanus-acellular pertussis vaccine cohort were included in the analysis. The VE against RGE (hospitalization and ED) was 100% (95% confidence interval [CI]: 87%-100%), whereas the VE against AGE was 59% (95% CI: 47%-68%). In...Continue Reading

Citations

Mar 26, 2013·Current Infectious Disease Reports·Penelope H Dennehy
Oct 14, 2011·The New England Journal of Medicine·Jennifer E CortesUmesh D Parashar
Sep 1, 2011·The Journal of Infectious Diseases·Roger I Glass
Sep 1, 2011·The Journal of Infectious Diseases·Ben A LopmanUmesh D Parashar
Jun 15, 2011·BMC Public Health·Mark H RozenbaumUNKNOWN Consensus Group on Dutch Rotavirus Vaccination (CoRoVa-Group)
Sep 21, 2010·Uirusu·Osamu Nakagomi, Toyoko Nakagomi
May 17, 2014·The Pediatric Infectious Disease Journal·Andrea Lo VecchioAlfredo Guarino
Jul 14, 2011·Current Opinion in Pediatrics·Kathryn E FayJoseph A Bocchini
Dec 23, 2011·Current Opinion in Pediatrics·Penelope H Dennehy
Jan 12, 2011·The Pediatric Infectious Disease Journal·Jacqueline E TateUmesh D Parashar
Jan 12, 2011·The Pediatric Infectious Disease Journal·Jacqueline E TateUmesh D Parashar
Jun 22, 2011·The Pediatric Infectious Disease Journal·Douglas H EspositoUmesh Parashar
Jul 20, 2011·The Pediatric Infectious Disease Journal·T Christopher MastEdmundo Sánchez
Oct 18, 2011·The Pediatric Infectious Disease Journal·Nicole Le SauxDoug Coyle
Sep 28, 2012·The Pediatric Infectious Disease Journal·Florence T WangJohn D Seeger
Jul 3, 2010·Paediatric Drugs·Keith GrimwoodRichard J Milne
Apr 19, 2011·European Journal of Pediatrics·Thomas HoffmannBirthe Hogh
Jun 19, 2012·Expert Review of Anti-infective Therapy·Philippe Lepage, Anne Vergison
Sep 8, 2010·Current Medical Research and Opinion·Christopher MorganLatha Parvataneni
May 21, 2013·Journal of the Pediatric Infectious Diseases Society·Angel Herrera GuerraKrow Ampofo
Dec 21, 2012·American Journal of Preventive Medicine·Sean T O'LearyAllison Kempe
Jul 14, 2012·Advances in Pediatrics·Penelope H Dennehy
Jun 30, 2012·The Lancet Infectious Diseases·Manish M PatelUmesh D Parashar
Dec 20, 2011·Vaccine·Carlo GiaquintoTimo Vesikari
Jul 9, 2011·Advances in Pediatrics·Ayesha Mirza, Mobeen H Rathore
Mar 30, 2011·Vaccine·Arnaud GagneurUNKNOWN IVANHOE investigators
Jun 15, 2011·Journal of Internal Medicine·J Gray
Mar 26, 2011·Annals of the New York Academy of Sciences·Michelle G GoveiaColette S Ranucci
Jul 2, 2016·Virusdisease·Nahed Abdel-HaqBasim I Asmar
Jul 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacqueline E Tate, Umesh D Parashar
Feb 9, 2016·The Pediatric Infectious Disease Journal·Margaret K DollCaroline Quach
Apr 16, 2014·Human Vaccines & Immunotherapeutics·Sudeep KarveSean D Candrilli
Sep 4, 2012·Vaccine·Terri B HydeUNKNOWN New Vaccine Introduction Impact Published Literature Working Group
Apr 24, 2014·Human Vaccines & Immunotherapeutics·Catherine YenUmesh D Parashar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.