Effectiveness of topical silicone gel and pressure garment therapy for burn scar prevention and management in children 12-months postburn: A parallel group randomised controlled trial.

Clinical Rehabilitation
Jodie WisemanZephanie Tyack

Abstract

The longer-term effectiveness of silicone and pressure burn scar interventions was evaluated at 12-months postburn. Parallel group, randomised trial. Hospital outpatient clinics, research centre. Children referred for burn scar management following grafted or spontaneously healed acute burn injuries or scar reconstruction surgery. Participants were randomised to: (1) topical silicone gel only, (2) pressure garment only, or (3) combined topical silicone gel and pressure garment. Primary outcomes were scar thickness (blinded ultrasound measurement) and itch intensity (caregiver proxy-report, numeric rating scale). Of 153 participants randomised who received the interventions (silicone n = 51, pressure garment n = 49, combined n = 53), 86 were followed-up at 12-months postburn (n = 34, n = 28, n = 24). No differences were identified for the primary outcomes using intention-to-treat analysis. Scar thickness mean difference (95% confidence interval) = 0.00 cm (-0.04, 0.05); -0.03 cm (-0.07, 0.02); 0.03 cm (-0.02, 0.08) and scar itch = 0.09 (-0.88, 1.06); -0.21 (-1.21, 0.79); 0.30 (-0.73, 1.32) for silicone vs pressure; silicone vs combined and combined vs pressure respectively. No serious adverse effects occurred. Similar to short-t...Continue Reading

References

Dec 2, 2000·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·R StewartT Binase
Jul 16, 2004·Plastic and Reconstructive Surgery·Lieneke J DraaijersPaul P M van Zuijlen
Nov 17, 2004·Annals of Internal Medicine·John P A IoannidisUNKNOWN CONSORT Group
Jun 10, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Daniel HarteAlison Porter-Armstrong
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
Jun 15, 2010·Burns : Journal of the International Society for Burn Injuries·Lai Hoi Yan CandyZheng Yong Ping
Oct 20, 2010·Administration and Policy in Mental Health·Sonja K SchoenwaldMichael A Southam-Gerow
Sep 19, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Martijn B A van der WalEsther Middelkoop
Apr 8, 2014·Burns : Journal of the International Society for Burn Injuries·Bernadette NedelecIsabelle Perrault
Jun 4, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Stan MonstreyLuc Téot
Aug 6, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Tobias EverettJason Hayes
Aug 28, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jeffrey C SchneiderColleen M Ryan
Jan 19, 2016·Burns : Journal of the International Society for Burn Injuries·Mieke AnthonissenEric Van den Kerckhove
Oct 7, 2016·Lancet·Celeste C FinnertyDavid N Herndon
Mar 16, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·C L LeonardiK Reich
Jul 16, 2017·The Patient·Binita M KamathBenjamin L Shneider
Apr 24, 2019·JAMA : the Journal of the American Medical Association·Edmund JuszczakKenneth Schulz

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