Effectiveness of transcutaneous electrical nerve stimulation for the treatment of migraine: a meta-analysis of randomized controlled trials

The Journal of Headache and Pain
Huimin TaoQi Wan

Abstract

Migraine is now ranked as the second most disabling disorder worldwide reported by the Global Burden of Disease Study 2016. As a noninvasive neurostimulation technique, transcutaneous electrical nerve stimulation(TENS) has been applied as an abortive and prophylactic treatment for migraine recently. We conduct this meta-analysis to analyze the effectiveness and safety of TENS on migraineurs. We searched Medline (via PubMed), Embase, the Cochrane Library and the Cochrane Central Register of Controlled Trials to identify randomized controlled trials, which compared the effect of TENS with sham TENS on migraineurs. Data were extracted and methodological quality assessed independently by two reviewers. Change in the number of monthly headache days, responder rate, painkiller intake, adverse events and satisfaction were extracted as outcome. Four studies were included in the quantitative analysis with 161 migraine patients in real TENS group and 115 in sham TENS group. We found significant reduction of monthly headache days (SMD: -0.48; 95% CI: -0.73 to - 0.23; P < 0.001) and painkiller intake (SMD: -0.78; 95% CI: -1.14 to - 0.42; P < 0.001). Responder rate (RR: 4.05; 95% CI: 2.06 to 7.97; P < 0.001) and satisfaction (RR: 1.85; 95% ...Continue Reading

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Citations

Jul 10, 2019·Current Pain and Headache Reports·Alan David KayeRichard D Urman
Feb 6, 2020·Cephalalgia : an International Journal of Headache·Maurizio BifulcoSimona Pisanti
Mar 21, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Kristen ZayanAnat Galor
Dec 4, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A Yu SokolovA V Amelin
Mar 12, 2021·Eye and Brain·Brandon S BakshAnat Galor
May 21, 2021·Pain Practice : the Official Journal of World Institute of Pain·Flávia S DominguesGuilherme A M de Barros

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