Effectiveness of treatments for medication-related osteonecrosis of the jaw: A systematic review and meta-analysis

The Journal of the American Dental Association
Mohamed El-RabbanyAmir Azarpazhooh

Abstract

The effectiveness of management strategies used for the treatment of medication-related osteonecrosis of the jaw (MRONJ) remains poorly understood. The authors evaluated systematically the effectiveness of the various treatment modalities used for MRONJ. The authors conducted a comprehensive search of MEDLINE, Embase, the Cochrane Library, and Scopus to identify randomized controlled trials, nonrandomized controlled trials, and prospective cohort studies to evaluate comparatively the effectiveness of management strategies for the treatment of MRONJ. The authors conducted the identification of eligible studies in duplicate and synthesized the extracted data by means of a meta-analysis, when feasible. The authors found 13 studies with a medium-to-high risk of bias that met the inclusion criteria of this review. The authors found that, compared with medical treatment of local antimicrobials with or without systemic antimicrobials, the study investigators associated surgical treatment with higher odds of complete resolution of the condition (2 studies; 76 participants; unadjusted odds ratio, 3.55; 95% confidence interval, 1.12 to 11.19). The effectiveness of other therapies, such as bisphosphonate drug holidays, teriparatide, and h...Continue Reading

Associated Clinical Trials

Citations

Feb 27, 2018·Journal of Clinical Periodontology·Márcio Diniz-FreitasJacobo Limeres
Dec 25, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Morten SchiodtDeborah P Saunders
Jul 23, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Noam YaromDeborah P Saunders
Sep 11, 2019·Head & Neck·Elen de Souza TolentinoMariliani C da Silva
Jun 27, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Vittorio MoraschiniJosé de Albuquerque Calasans-Maia
Oct 7, 2017·The Cochrane Database of Systematic Reviews·Natalie H Beth-TasdoganOliver Zolk
Dec 2, 2020·International Journal of Environmental Research and Public Health·Na Rae ChoiDae Seok Hwang
Oct 23, 2020·International Journal of Oral Science·Lina HeYumei Niu

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