PMID: 59185Jul 17, 1976

Effectiveness of Zagreb antivenom against envenoming by the adder, Vipera berus

Lancet
R D Theakston, H A REID

Abstract

Rhesus monkeys injected subcutaneously with 2, 3, or 4 mg Vipera berus venom per kg body-weight all died in shock. With 1 mg/kg the monkey had severe systemic and local effects taking 12 days to resolve. Five monkeys each recieved 4 mg/kg (a triple-lethal dose) and Zagreb antivenom was injected intravenously 1-4 hours after venom injection. The contents of 2 ampoules (10-8 ml) up to 3 hours later saved the monkeys; at 4 hours later the monkey died. But when the antivenom dose was raised to 16-2 ml 4 hours after venom, it saved the monkey. In addition to saving life, the antivenom greatly reduced the local venom effects. It is suggested that the results justify giving Zagreb antivenom to patients with severe adder-bite poisoning; and it should also be considered in adults to minimise morbidity from local effects.

Citations

Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·G S BaileyD Smith
Aug 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·D SmithJ Landon
Jan 1, 1994·Journal of Internal Medicine·C Karlson-Stiber, H Persson
May 1, 1979·Archives of Disease in Childhood·R N Wild
Jun 17, 1978·British Medical Journal·H A REID
Jul 29, 1978·British Medical Journal·D A Warrell
Nov 26, 2005·BMJ : British Medical Journal·D A Warrell
Dec 18, 2012·Emergency Medicine Journal : EMJ·James Michael CoulsonJohn Paul Thompson
Sep 1, 1993·Archives of Emergency Medicine·D J Harborne
Sep 1, 1996·Journal of Accident & Emergency Medicine·C J Reading
Jun 1, 1988·Archives of Emergency Medicine·R S Moore
Feb 25, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·C Karlson-StiberH Persson
Jul 1, 1987·Acta paediatrica Scandinavica·I Cederholm, C Lennmarken
Mar 30, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Thomas LambMichael Eddleston
Jun 1, 1990·Journal of the Royal Army Medical Corps·A Hawley
Dec 1, 1985·Journal of the Royal Society of Medicine·Y L Lau, A P Kenna
Jan 1, 1981·Acta Medica Scandinavica·H Persson, B Irestedt

Related Concepts

Anthropoidea
Antivenin
Hypovolemic Shock
Snake Bites

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

British Medical Journal
H A REID
Archives of Disease in Childhood
R N Wild
© 2021 Meta ULC. All rights reserved