Effectiveness of ZnCl2 in protecting against nephrotoxicity induced by HgCl2 in newborn rats

Ecotoxicology and Environmental Safety
Nilce Coelho Peixoto, Maria E Pereira

Abstract

This work investigated the preventive effects of ZnCl(2) on renal and hepatic alterations induced by HgCl(2) in young rats. Wistar rats of 3 days old were treated (s.c.) on consecutive days with saline or ZnCl(2) 27 mg/kg/day from the 3rd to the 7th and with saline or HgCl(2) 5.0mg/kg/day from the 8th to the 12th day of life. Pups were sacrificed 24h after the last dose and samples were collected. The creatinine and urea dosages, used as renal parameters, presented increases of 35% and 500%, respectively. The alanine aminotransferase and lactic dehydrogenase activities, used as hepatic parameters, presented a decrease (40%) and no alteration, respectively, by mercury exposure. The glycemia was diminished and the hepatic glycogen was not modified by mercury. All the mercury effects were prevented by zinc. These results suggest that mercury intoxication of young rats alters the renal function but does not modify the hepatic parameters, and previous exposure to zinc is able to avoid the renal damage.

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Citations

Mar 14, 2012·Cell Biology and Toxicology·Rafael Porto IneuMaria Ester Pereira
Jun 24, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Tiago da Luz FiuzaMaria Ester Pereira
May 19, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C FranciscatoM E Pereira
May 9, 2008·Ecotoxicology and Environmental Safety·A S JósêM E Pereira
Jul 20, 2012·Journal of Biochemical and Molecular Toxicology·Lucélia Moraes-SilvaMaria Ester Pereira
Mar 15, 2012·Cell Biology International·Lucélia Moraes-SilvaMaria Ester Pereira
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Vitor Antunes OliveiraMaria Ester Pereira
Apr 1, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Vitor Antunes OliveiraMaria Ester Pereira
May 15, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cláudia S OliveiraMaria E Pereira
Dec 25, 2010·Ecotoxicology and Environmental Safety·C FranciscatoM E Pereira
Dec 9, 2016·The Journal of Obstetrics and Gynaecology Research·Zhanping WengXianghong Ji
Oct 12, 2017·Journal of Toxicology and Environmental Health. Part a·Antonio Ivanildo PinhoJeferson Luis Franco
May 31, 2018·Journal of Toxicology and Environmental Health. Part a·Lucélia Moraes-SilvaMaria Ester Pereira
Jun 6, 2018·Frontiers in Molecular Neuroscience·Francisco B TeixeiraRafael R Lima
Jun 21, 2020·Environmental Science and Pollution Research International·Zuzana Kompišová BallováKatarína Pinterová
Jul 17, 2020·Environmental Science and Pollution Research International·Vitor Antunes OliveiraCláudia Sirlene Oliveira

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