Effectivity of Pancreatic Enzyme Replacement Therapy in Malnourished Children

Journal of Pediatric Gastroenterology and Nutrition
Burcu GüvenAkkız Şahin Yaşar

Abstract

Malnutrition is commonly seen in children with exocrine pancreatic insufficiency (EPI). Pancreatic enzyme replacement therapy (PERT) is the mainstay treatment of acute malnutrition in children detected with a disease closely associated with EPI (eg, cystic fibrosis). The effectiveness of PERT in children with malnutrition without any chronic disease, however, remains unclear. The aim of this study was to investigate the effectiveness of PERT on weight gain and EPI in children classified as moderately and severely malnourished according to the World Health Organization (WHO) classification. The study included a total of 40 children aged 2-16 years who were classified as moderately and severely malnourished according to the WHO classification. The patients were randomly divided into 2 groups: PERT group (n = 20) received 2000 U lipase/kg/day (in 4 doses) in addition to hypercaloric enteral supplements and control group received hypercaloric enteral supplements only. In both groups, anthropometric measurements and the assessment of fecal elastase-1 (FE-1) levels were performed both at first admission and at the end of the 8-week treatment period. On the basis of WHO classification, 10 (25%) children were classified as severely mal...Continue Reading

References

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Apr 29, 2015·Journal of Pediatric Gastroenterology and Nutrition·Christopher J TaylorMichael Wilschanski
Sep 16, 2017·The Journal of Pediatrics·Rosalie H BartelsWieger P Voskuijl
Oct 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Rosalie H BartelsWieger P Voskuijl

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Citations

Jul 9, 2020·Journal of Pediatric Gastroenterology and Nutrition·Rhys Dore
Aug 11, 2020·Current Opinion in Pediatrics·Zachary M Sellers

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