Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections

Immunological Reviews
Peter C DohertyP G Stevenson

Abstract

The rules for T-cell-mediated control of viruses that infect via the respiratory mucosae show both common themes and differences, depending on the nature of the pathogen. Virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are the key effectors of virus clearance in mice infected with both negative strand RNA viruses (influenza and Sendai) and a DNA virus, the murine gamma-herpesvirus-68 (MHV-68). Recently completed experiments establish that these activated CD8+ T cells indeed operate primarily via contact-dependent lysis. Perforin-mediated cytotoxicity seems to be the preferred mode, though a Fas-based mechanism can apparently serve as an alternative mechanism. Immune CD4+ T cells functioning in the absence of the CD8+ subset cannot eliminate MHV-68 from lung epithelial cells, are somewhat less efficient than the CD8+ CTLs at clearing the RNA viruses, and are generally ineffectual in mice that lack B lymphocytes. Though cytokine secretion by CD4+ and CD8+ T cells in the virus-infected lung may promote both T-cell extravasation and macrophage activation, such processes are not alone sufficient to deal consistently with any of these infections. However, CD4+ T help is mandatory for an effective B-cell response, and can operate t...Continue Reading

References

Dec 1, 1992·The Journal of General Virology·N P Sunil-ChandraA A Nash
Jul 1, 1991·The Journal of General Virology·M C EichelbergerP C Doherty
Feb 1, 1990·Immunology Today·C Mackworth-Young
Oct 1, 1989·The Journal of Experimental Medicine·R BujdosoI McConnell
Jan 1, 1986·Current Topics in Microbiology and Immunology·G L Ada, P D Jones
Jan 1, 1974·Transplantation Reviews·P C Doherty, R M Zinkernagel
Sep 1, 1984·The Journal of Experimental Medicine·A E LukacherT J Braciale
May 10, 1984·The New England Journal of Medicine·J W SixbeyJ S Pagano
Dec 1, 1994·The Journal of Experimental Medicine·L M BradleyS L Swain
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M WalshW R Clark
Dec 1, 1994·European Journal of Immunology·S M MarianiP H Krammer
Feb 1, 1995·Journal of Virology·X Y MoP C Doherty
Aug 1, 1994·Current Opinion in Immunology·A A Nash, N P Sunil-Chandra
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·L G GuidottiF V Chisari
Aug 1, 1993·Current Opinion in Immunology·P C Doherty
Nov 1, 1993·The Journal of Experimental Medicine·M B GrahamT J Braciale

❮ Previous
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Citations

May 6, 1999·European Journal of Immunology·J B HaanenT N Schumacher
Mar 10, 2011·Cellular and Molecular Life Sciences : CMLS·E J A M Sijts, P M Kloetzel
Apr 12, 2007·Wiener medizinische Wochenschrift·Giovanni AlmanzarBeatrix Grubeck-Loebenstein
Oct 16, 2012·Journal of Clinical Immunology·Robert A EisenbergKathleen E Sullivan
Mar 24, 2005·Microbes and Infection·Andrew Evan WilliamsTracy Hussell
Oct 3, 1999·Veterinary Immunology and Immunopathology·K ErikssonB Blacklaws
Mar 30, 2002·Trends in Immunology·Dominik WodarzAllan Randrup Thomsen
May 10, 2003·Trends in Immunology·Jennifer E Snyder, Tim R Mosmann
Dec 22, 1999·The Proceedings of the Nutrition Society·S N Han, S N Meydani
Aug 24, 2005·Nature Immunology·Paul Klenerman, Ann Hill
Apr 20, 2006·Nature Immunology·Peter C DohertyPaul G Thomas
Jan 11, 2007·Immunology and Cell Biology·Nicole L La GrutaPeter C Doherty
Apr 6, 2004·Immunology and Cell Biology·Matthias Regner, Arno Müllbacher
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carole GuillonneauStephen J Turner
Mar 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jerry R AldridgePaul G Thomas
Jun 6, 2000·The Journal of Experimental Medicine·G E PriceD Moskophidis
Oct 9, 2002·The Journal of Experimental Medicine·Eulogia RománSusan L Swain
Oct 22, 2003·The Journal of Experimental Medicine·Ian R HumphreysTracy Hussell
Jun 9, 2004·The Journal of Experimental Medicine·Behazine CombadiereBrigitte Autran
Feb 16, 2008·The Journal of Infectious Diseases·Danuta M SkowronskiGaston De Serres
Mar 29, 2001·Viral Immunology·N W MartenC C Bergmann
Sep 27, 2001·Viral Immunology·J M Moser, A E Lukacher
Oct 30, 2003·Viral Immunology·Fredrik AronssonKrister Kristensson
Jul 29, 2004·Viral Immunology·Susan L SwainDavid L Woodland
Mar 17, 2004·Viral Immunology·Sally R SarawarFrancesca Giannoni
Oct 31, 2003·AIDS Research and Human Retroviruses·Sandra CohenCatarina E Hioe
Apr 10, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shahram Salek-Ardakani, Michael Croft
Jul 3, 2007·Viral Immunology·Maryna C Eichelberger

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