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Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice

Alzheimer's Research & Therapy

Jan 15, 2020

Helen CrehanCynthia A Lemere

Abstract

Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer's disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive emerging treatment strategy for AD. We address the question o...read more

Mentioned in this Paper

Laboratory mice
Species
Genetic Engineering
Microglia
Transgenes
Phagocytosis
Fc-gamma receptor II
Imaging Studies
High Affinity Immunoglobulin Gamma Fc Receptor I
Phagocytes
2
1
Paper Details
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Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice

Alzheimer's Research & Therapy

Jan 15, 2020

Helen CrehanCynthia A Lemere

PMID: 31931873

DOI: 10.1186/s13195-019-0579-8

Abstract

Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer's disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive emerging treatment strategy for AD. We address the question o...read more

Mentioned in this Paper

Laboratory mice
Species
Genetic Engineering
Microglia
Transgenes
Phagocytosis
Fc-gamma receptor II
Imaging Studies
High Affinity Immunoglobulin Gamma Fc Receptor I
Phagocytes
2
1

Similar Papers Found In These Feeds

Proteostasis

Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.

Misfolding & Aggregation Diseases

Misfolding and aggregation of proteins can lead to several diseases. For instance, misfolding of prion or tau proteins are associated with several neurodegenerative diseases. Here is the latest research on diseases caused by protein misfolding and aggregation.

Related Papers

Neurobiology of Aging

An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice

Neurobiology of AgingOctober 11, 2015
Jeffrey L FrostCynthia A Lemere
Paper Details
References
  • References55
  • Citations
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  • References55
  • Citations
  • quote and clock

    No citations available

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