Effects and applications of ultrashort-lived prehydrated electrons in radiation biology and radiotherapy of cancer

Mutation Research
Qing-Bin Lu

Abstract

The subpicosecond-lived prehydrated electron (e(pre)(-)) is a fascinating species in radiation biology and radiotherapy of cancer. Using femtosecond time-resolved laser spectroscopy, we have recently resolved that e(pre)(-) states are electronically excited states and have lifetimes of approximately 180 fs and approximately 550 fs, after the identification and removal of a coherence spike, respectively. Notably, the weakly bound e(pre)(-) (< 0 eV) has the highest yield among all the radicals generated in the cell during ionizing radiation. Recently, it has been demonstrated that dissociative electron transfer (DET) reactions of e(pre)(-) can lead to important biological effects. By direct observation of the transition states of the DET reactions, we have showed that DET reactions of e(pre)(-) play key roles in bond breakage of nucleotides and in activations of halopyrimidines as potential hypoxic radiosensitizers and of the chemotherapeutic drug cisplatin in combination with radiotherapy. This review discusses all of these findings, which may lead to improved strategies in radiotherapy of cancer, radioprotection of humans and in discovery of new anticancer drugs.

Citations

Jun 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ting LuoQing-Bin Lu
Jun 15, 2011·The Journal of Chemical Physics·Martin K FischerHristo Iglev
Jul 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jenny NguyenQing-Bin Lu
Jul 6, 2014·Journal of Molecular Recognition : JMR·Soma BanerjeeSamir Kumar Pal
Nov 25, 2011·DNA Repair·Michael J Daly
Aug 10, 2016·Journal of the American Chemical Society·Marc P CoonsJohn M Herbert
Mar 10, 2018·Chemistry : a European Journal·Robin SchürmannIlko Bald
Aug 8, 2014·Physical Chemistry Chemical Physics : PCCP·Hsing-Yin ChenSodio C N Hsu
Aug 6, 2020·The Journal of Chemical Physics·Madhubani MukherjeeAchintya Kumar Dutta
Feb 28, 2016·Molecular Cancer Therapeutics·Chun-Rong WangQing-Bin Lu
Nov 5, 2020·International Journal of Molecular Sciences·Thomas F M LuxfordJaroslav Kočišek
Aug 8, 2021·International Journal of Molecular Sciences·Yingxia GaoLéon Sanche
Oct 5, 2010·Journal of the American Chemical Society·Chun-Rong Wang, Qing-Bin Lu
Nov 12, 2013·The Journal of Physical Chemistry. B·B BehmandD J Hunting

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