PMID: 1209785Jan 1, 1975Paper

Effects and interactions of oxygen and prostaglandins on the tone of the isolated human umbilical artery

Upsala Journal of Medical Sciences
T Tuvemo, K Strandberg

Abstract

Prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) were found to be equipotent contractors of the isolated human umbilical artery (HUA) in the concentration range 0.2-40 mug/ml. Prostaglandin E1 (PGE1) relaxed HUA at 0.1-3.0 mug/ml, whereas at 10-50 mug/ml contraction occurred. PGE2 was significantly more potent at a PO2 of 102 mmHg than at 27, 48 and above 400 mmHg. An increase in PO2 per se (27- greater than 400 mmHg) resulted occasionally in minor increases in the tone of the HUA. Such effects of oxygen had a lag period of 10-15 min. It is suggested that an increased formation of prostaglandins in the umbilical artery at birth is a more likely cause of the closure of the vessel than an increase in PO2.

References

Jan 1, 1976·Biology of the Neonate·C E JonssonM Hamberg
Jan 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·B V Lewis
Jun 1, 1968·Circulation Research·L G EltheringtonK L Melmon
Jan 1, 1974·Biology of the Neonate·A C Yao, J Lind
May 1, 1972·Canadian Journal of Physiology and Pharmacology·M K ParkD C Dyer
Nov 1, 1973·The American Journal of Physiology·X Nair, D C Dyer
Nov 1, 1973·Prostaglandins·T Tuvemo, L Wide
Jan 1, 1973·Journal of Perinatal Medicine·A HuchG Rooth
Jun 1, 1974·European Journal of Pharmacology·M Hollingsworth
Jul 1, 1970·Canadian Journal of Physiology and Pharmacology·I Bor, W G Guntheroth
Apr 1, 1972·The Journal of Physiology·F W Campbell, J J Kulikowski
Jan 1, 1966·Acta Anaesthesiologica Scandinavica. Supplementum·K BehrO P Norlander
May 1, 1968·Circulation Research·N S Assali, J Kirschbaum TH Dilts PV
Jun 1, 1968·The Journal of Obstetrics and Gynaecology of the British Commonwealth·K Hillier, S M Karim
Jan 1, 1966·The Journal of Physiology·A G CampbellG B James
Nov 1, 1963·The Journal of Physiology·V KOVALCIK
Feb 15, 1965·American Journal of Obstetrics and Gynecology·Z K STEMBERAJ JANDA

❮ Previous
Next ❯

Citations

Jun 1, 1978·Prostaglandins·K PomerantzP Ramwell
Feb 1, 1976·Acta Physiologica Scandinavica·T TuvemoB Samuelsson
Jan 1, 1983·General Pharmacology·A O ElkhawadM Khogali
Oct 1, 1990·American Journal of Obstetrics and Gynecology·R P PaulickA M Rudolph

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.